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Clinicopathological Characteristics and Prognostic Factors of Synchronous Endometrial and Ovarian Cancers—A Single-Institute Review of 43 Cases
  1. Vandana Jain, MS*,
  2. Rupinder Sekhon, MD*,
  3. Sunil Pasricha, MD,
  4. Shveta Giri, MD*,
  5. Kanika Batra Modi, DNB*,
  6. Eliza Shrestha, MD*,
  7. Dharma Ram, DNB* and
  8. Sudhir Rawal, MCH*
  1. *Department of Uro-Gynae Oncology, Rajiv Gandhi Cancer Institute and Research Centre; and
  2. Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi India.
  1. Address correspondence and reprint requests to Vandana Jain, MS, Department of Uro-Gynae Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-V, Rohini, Delhi 110085, India. E-mail:


Objectives The objectives of our study were to demonstrate the clinicopathological characteristics and determine the prognostic factors for women with synchronous primary cancers of the endometrium and ovary.

Methods A retrospective analysis of 43 pathologically proven cases of synchronous primary endometrial and ovarian cancers diagnosed between January 2005 and December 2015 was carried out. Patients with uterine sarcomas, carcinosarcomas, borderline tumors, and nonepithelial tumors of the ovary and patients who received neoadjuvant chemotherapy were excluded from the study. Disease-free survival (DFS) and overall survival (OS) rates were calculated using the Kaplan-Meier method. Multivariate analysis to determine independent prognostic factors was performed using the Cox regression model.

Results Mean age at diagnosis was 48.49 years. The most common presenting symptom was abnormal uterine bleeding in 58.2% of the patients. Nineteen patients (44.2%) were obese, and 13 patients (30.2%) were overweight. Twelve patients (30%) were nulliparous, and 25 (58.2%) were premenopausal; 76.7% of the patients received adjuvant treatment after surgery. Mean follow-up period was 48.9 months. Twelve patients developed recurrence, and 7 patients died of recurrent disease. The 5-year DFS for all patients was 65.13%, and the 5-year OS was 79.75%. The 118-month DFS and 118-month OS were 65.13% and 72.50%, respectively. On multivariate analysis, grade 3 disease for both endometrial and ovarian cancers and presence of lymphovascular space invasion were associated with significantly worse 118-month DFS and OS, respectively.

Conclusions Women with synchronous primary endometrial and ovarian cancers are young, nulliparous, obese, and premenopausal and have a favorable overall prognosis. Grade 3 disease at both sites and presence of lymphovascular space invasion are independent prognostic factors for recurrence and survival, respectively.

  • Endometrial cancer
  • Ovarian cancer
  • Prognostic factors
  • Synchronous cancer

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  • The authors declare no conflicts of interest.