Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition

Kari L. Ring; Melinda S. Yates; Rosemarie Schmandt; Michaela Onstad; Qian Zhang; Joseph Celestino; Suet-Ying Kwan; Karen H. Lu

doi:10.1097/IGC.0000000000000960

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Basic Science

Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition

Authors

Kari L. Ring Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Melinda S. Yates Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Rosemarie Schmandt Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Michaela Onstad Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Qian Zhang Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Joseph Celestino Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Suet-Ying Kwan Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles
Karen H. Lu Departments of Gynecologic Oncology and Reproductive Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX. PubMed articles Google scholar articles

Address correspondence and reprint requests to Karen H. Lu, MD, Department of Gynecologic Oncology and Reproductive Medicine, 1155 Hermann Pressler Dr, Unit 1362 Houston, TX 77030. E-mail: khlu@mdanderson.org.

Citation

Ring KL, Yates MS, Schmandt R, et al

Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition

International Journal of Gynecologic Cancer 2017;27:854-862.

Publication history

Received October 14, 2016
First published June 1, 2017.

Online issue publication

February 26, 2019

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