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European Society of Gynaecological Oncology Guidelines for the Management of Patients With Vulvar Cancer
  1. Maaike H.M. Oonk, MD, PhD*,
  2. François Planchamp, PhD,
  3. Peter Baldwin, MD,
  4. Mariusz Bidzinski, MD, PhD§,
  5. Mats Brännström, MD, PhD,
  6. Fabio Landoni, MD, PhD,
  7. Sven Mahner, MD, PhD#,
  8. Umesh Mahantshetty, MD**,
  9. Mansoor Mirza, MD,,
  10. Cordula Petersen, MD, PhD,,
  11. Denis Querleu, MD, PhD,
  12. Sigrid Regauer, MD§§,
  13. Lukas Rob, MD, PhD∥∥,
  14. Roman Rouzier, MD¶¶,
  15. Elena Ulrikh, MD, PhD##,
  16. Jacobus van der Velden, MD, PhD***,
  17. Ignace Vergote, MD, PhD†††,
  18. Linn Woelber, MD, PhD‡‡‡ and
  19. Ate G.J. van der Zee, MD, PhD*
  1. * University Medical Center, Groningen, the Netherlands;
  2. Institut Bergonié, Bordeaux, France;
  3. Addenbrooke’s Hospital, Cambridge, United Kingdom;
  4. § Hollycross Oncology Center, Kielce, Poland;
  5. University of Gothenburg, Gothenburg, Sweden;
  6. European Institute of Oncology, Milano, Italy;
  7. # University of Munich, Munich, Germany;
  8. ** Tata Memorial Hospital, Mumbai, India;
  9. †† Finsen Centre, Rigshospitalet, Copenhagen, Denmark;
  10. ‡‡ University Medical Center, Hamburg, Germany;
  11. §§ Medical University, Graz, Austria;
  12. ∥∥ Charles University, Prague, Czech Republic;
  13. ¶¶ Pierre and Marie Curie University, Paris, France;
  14. ## St Petersburg N. N. Petrov Research Institute, St Petersburg, Russia;
  15. *** Academic Medical Center, Amsterdam, Netherlands;
  16. ††† University Hospital, Leuven, Belgium;
  17. ‡‡‡ University Medical Center, Hamburg, Germany.
  1. Address correspondence and reprint requests to Ate G. J. van der Zee, MD, PhD, University Medical Center Groningen, PO Box 30.001 9700 RB, Groningen, the Netherlands. E-mail: a.g.j.van.der.zee{at}umcg.nl.

Abstract

Objective The aim of this study was to develop clinically relevant and evidence-based guidelines as part of European Society of Gynaecological Oncology’s mission to improve the quality of care for women with gynecologic cancers across Europe.

Methods The European Society of Gynaecological Oncology Council nominated an international development group made of practicing clinicians who provide care to patients with vulvar cancer and have demonstrated leadership and interest in the management of patients with vulvar cancer (18 experts across Europe). To ensure that the statements are evidence based, the current literature identified from a systematic search has been reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the professional experience and consensus of the development group (expert agreement). The guidelines are thus based on the best available evidence and expert agreement. Prior to publication, the guidelines were reviewed by 181 international reviewers including patient representatives independent from the development group.

Results The guidelines cover diagnosis and referral, preoperative investigations, surgical management (local treatment, groin treatment including sentinel lymph node procedure, reconstructive surgery), radiation therapy, chemoradiation, systemic treatment, treatment of recurrent disease (vulvar recurrence, groin recurrence, distant metastases), and follow-up.

  • Algorithms
  • Guidelines
  • Quality indicators
  • Vulvar cancer

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Footnotes

  • The authors declare no conflicts of interest.

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