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Recurrent Ovarian Cancer: The Role of Radiation Therapy
  1. Francesca De Felice, PhD*,
  2. Claudia Marchetti, PhD,
  3. Andrea Di Mino, MD*,
  4. Innocenza Palaia, PhD,
  5. Ilaria Benevento, MD*,
  6. Angela Musella, MD,
  7. Daniela Musio, MD* and
  8. Vincenzo Tombolini, FP*
  1. * Department of Radiotherapy, Policlinico Umberto I, and
  2. Department of Gynecological and Obstetrical Sciences and Urological Sciences, Sapienza University of Rome, Rome, Italy.
  1. Address correspondence and reprint requests to Francesca De Felice, PhD, Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. E-mail: fradefelice{at}


Objective The aim of this review was to present the current radiation therapy status in recurrent ovarian cancer (OC) and explore potential solution to improve clinical outcomes in this setting of patients.

Materials and Methods PubMed search was performed. An attempt was made to include all relevant studies. Pertinent references cited in selected articles were also considered.

Results The role of radiation therapy in recurrent OC needs to be defined. This is the largest reported analysis of published data.

Conclusions Chemotherapy is the mainstay of recurrent OC treatment but prognosis remains very poor, and novel therapies are required to be integrated into this consolidated treatment regimen. Radiation therapy represents a valid alternative approach, even if no clear guidelines are available concerning it.

  • Ovarian cancer
  • Recurrence
  • Chemotherapy
  • Surgery
  • Radiotherapy
  • Whole-abdominopelvic irradiation
  • Involved field

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  • The authors declare no conflicts of interest.