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Morbidity of Staging Inframesenteric Paraaortic Lymphadenectomy in Locally Advanced Cervical Cancer Compared With Infrarenal Lymphadenectomy
  1. Clothilde Petitnicolas, MD*,
  2. Henri Azaïs, MD,
  3. Louise Ghesquière, MD,
  4. Emmanuelle Tresch-Bruneel, MSc,
  5. Abel Cordoba, MD§,
  6. Fabrice Narducci, MD*,
  7. Lucie Bresson, MD* and
  8. Eric Leblanc, MD*
  1. *Department of Gynecological Oncology Surgery, Centre de Lutte Contre le Cancer Oscar Lambret, Lille Cedex;
  2. Department of Gynecology, Hôpital Jeanne de Flandre, CHRU Lille; and Departments of
  3. Statistics and
  4. §Radiation Oncology, Centre de Lutte Contre le Cancer Oscar Lambret, Lille Cedex, France.
  1. Address correspondence and reprint requests to Clothilde Petitnicolas, MD, Department of Gynecological Oncology Surgery, Centre de Lutte Contre le Cancer Oscar Lambret, 3 rue Combemale, 59020 Lille Cedex, France. E-mail:


Objective Extended-field chemoradiation is typically used for the management of patients with locally advanced cervical cancer. Given the low rate of skipped metastases above the inferior mesenteric artery, ilioinframesenteric dissection seems to be an acceptable pattern of paraaortic lymph node dissection (LND). Our objective is to compare the surgical morbidity of inframesenteric LND (IM-LND) with infrarenal LND (IR-LND).

Methods In our center, all of the patients with locally advanced cervical cancer and negative magnetic resonance imaging and positron emission tomography–computed tomography imaging at the paraaortic level were offered laparoscopic staging including a diagnostic laparoscopy followed, if negative, by an extraperitoneal paraaortic lymphadenectomy. From January 2011 to September 2015, we included patients who had paraaortic LND from both common iliac bifurcations and divided them into 2 groups according to dissection pattern: to the inferior mesenteric artery (IM-LND) level or to the left renal vein (IR-LND) level. The perioperative and postoperative data were retrospectively recorded.

Results A total of 119 women were included in our study: 56 in the IM-LND group and 63 in the IR-LND group. There was no difference in the patients' characteristics between groups. Regarding the surgical procedure, the operating time was shorter in the IM-LND group than the IR-LND group, 174 ± 50 minutes versus 209 ± 61 minutes (P = 0.001), respectively. There was no significant difference in intra- and postoperative complications, overall survival, or progression-free survival.

Conclusions In our series, exclusive IM-LND surgery is faster than IR-LND and results in similar morbidity and survival rates. These results confirm the feasibility and the applicability of IM-LND to simplify the surgical procedure without impacting survival. More patients should be included in the study to demonstrate the lower rate of morbidity.

  • Cervical cancer
  • Paraaortic lymphadenectomy
  • Laparoscopy
  • Morbidity

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  • The authors declare no conflicts of interest.