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Preoperative Predictive Factors for Complete Cytoreduction and Survival Outcome in Epithelial Ovarian, Tubal, and Peritoneal Cancer After Neoadjuvant Chemotherapy
  1. Min-Hyun Baek, MD, PhD*,,
  2. Shin-Wha Lee, MD, PhD,
  3. Jeong-Yeol Park, MD, PhD,
  4. Chae Chun Rhim, MD, PhD*,
  5. Dae-Yeon Kim, MD, PhD,
  6. Dae-Shik Suh, MD, PhD,
  7. Jong-Hyeok Kim, MD, PhD,
  8. Yong-Man Kim, MD, PhD,
  9. Young-Tak Kim, MD, PhD and
  10. Joo-Hyun Nam, MD, PhD
  1. *Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Anyang; and
  2. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  1. Address correspondence and reprint requests to Dae-Yeon Kim, MD, PhD, Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. E-mail: kdyog@amc.seoul.kr.

Abstract

Objective The study aims to identify preoperative predictors of complete cytoreduction and early recurrence and death in epithelial ovarian, tubal, and peritoneal cancer after neoadjuvant chemotherapy (NACT).

Methods We performed a retrospective analysis of 85 patients who underwent 3 cycles of NACT. Patients were divided into 2 groups according to residual tumor at interval debulking surgery (IDS), and clinicopathologic, surgical, and follow-up data were compared.

Results Cancer antigen 125 (CA-125) levels before the IDS after completion of NACT were higher in the residual tumor group (42.0 vs 116.6 U/mL, P = 0.006). The drop rate of CA-125 after NACT was higher in the no residual tumor group (96.8% vs 89.9%, P = 0.001). Patients with residual tumor showed lower disease-free and overall survival outcomes than patients with no residual tumor. In univariate analysis, CA-125 of 100 U/mL or less before IDS and a drop rate after NACT greater than 80% were preoperative predictive factors for complete cytoreduction. In multivariate analysis, a drop rate of CA-125 after NACT greater than 80% was an independent preoperative predictive factor for complete cytoreduction (P = 0.002). Progressive disease on follow-up image during NACT was an independent preoperative predictive factor for early recurrence and death (P < 0.001, both).

Conclusions A significant drop of CA-125 after NACT and progressive disease on follow-up image are independent preoperative predictors for complete cytoreduction and early recurrence and death.

  • Ovarian cancer
  • Complete cytoreduction
  • Survival outcome
  • Predictive factor
  • Neoadjuvant chemotherapy
  • Interval debulking surgery

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  • The authors declare no conflicts of interest.

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