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A New MicroRNA Expression Signature for Cervical Cancer
  1. Ping Sun,
  2. Yong Shen, PhD,
  3. Jiao-Mei Gong, MD,
  4. Li-Li Zhou,
  5. Jia-He Sheng and
  6. Fu-Jiao Duan, MD
  1. * Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital;
  2. Department of Clinical Laboratory, the Second Affiliated Hospital of Zhengzhou University; and
  3. Department of Obstetrics and Gynecology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
  1. Address correspondence and reprint requests to Yong Shen, PhD, Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road, Jinshui District, Zhengzhou 450008, PR China. E-mail: sy8701{at}hotmail.com.

Abstract

Background Cervical cancer is the second most common cancer among women worldwide. The potential of microRNAs as novel biomarkers in cervical cancer is growing.

Objectives In this study, we investigated the functions and targets of miR-466 in cervical cancer tissues.

Methods Fresh cervical tissues were obtained from 157 patients with cervical cancer, cervical intraepithelial neoplasia (CIN), and healthy controls, and the tissues were immediately frozen in liquid nitrogen until use. The RNA was extracted and quantitative real-time polymerase chain reaction (PCR) was performed.

Results A total of 157 participants were summarized, including 56 patients with cervical cancer, 60 patients with CIN, and 49 healthy controls. The expression levels of miR-466 in cervical cancers (0.68) were higher than that in healthy controls (0.082) (P < 0.01). The average fold changes of miR-466 in the patients with CIN group and people group were 0.28 and 0.082, respectively (P < 0.01). It was a statistically significant difference in patients with lymph node involvement (P = 0.022). However, the expression of miR-466 was not correlated with International Federation of Gynecology and Obstetrics stages, tumor size, or vascular invasion (P = 0.506, P = 0.667, and P = 0.108, respectively).

Conclusions Our results indicate that the aberrant expression of miR-466 is closely associated with the occurrence and development of cervical cancer.

  • miR-466
  • miRNAs
  • Cervical cancer
  • Cervical intraepithelial neoplasia
  • HPV

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Footnotes

  • The authors declare no conflicts of interest.

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