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Effect of Physical Activity on Quality of Life as Perceived by Endometrial Cancer Survivors: A Systematic Review
  1. Oluwole Adeyemi Babatunde, MBBS, MPH,
  2. Swann A. Adams, PhD,
  3. Olubunmi Orekoya, MBBS, MPH,
  4. Karen Basen-Engquist, PhD and
  5. Susan E. Steck, PhD
  1. * Department of Epidemiology and Biostatistics, and
  2. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC; and
  3. Department of Behavioral Science, Cancer Prevention and Population Sciences, University of Texas MD Anderson Cancer Center, Houston, TX.
  1. Address correspondence and reprint requests to Oluwole Babatunde, Department of Epidemiology and Biostatistics and South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Cubicle 14, 915 Greene Street, Columbia, SC 29208. E-mail: oab{at}


Purpose A combination of the relatively high prevalence among gynecologic cancers, high survival, and the myriads of factors that negatively impact the quality of life (QoL) among endometrial cancer (EC) survivors underscores the potential benefits of meeting guideline physical activity (PA) guidelines of 150 minutes per week among EC survivors. The objective of the present systematic review was to collate and critically evaluate the currently available literature on the effects of PA on QoL among EC survivors.

Methods Medline and Web of Science databases were searched for articles on EC, QoL, and PA. We also inspected bibliographies of relevant publications to identify related articles. Our search criteria yielded 70 studies, 7 of which met the inclusion criteria.

Results Of the 7 studies examined, 2 of them were intervention studies, whereas 5 were cross-sectional studies. Meeting guideline PA was significantly associated with better QoL score in 4 of the 5 cross-sectional studies.

Conclusions Results from the cross-sectional studies suggest that EC survivors’ inactivity is significantly correlated with poorer QoL. This correlation was worse among obese survivors compared with normal weight survivors. Endometrial cancer survivors may benefit from interventions that incorporate PA. More randomized intervention studies among EC survivors are needed to add to this body of evidence.

  • Cancer
  • Carcinoma
  • Endometrial
  • Exercise
  • Fatigue
  • Physical activity
  • Quality of life

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  • The authors declare no conflicts of interest.