Article Text

Download PDFPDF

Outcome of Appendicectomies at Surgery for Mucinous Ovarian Neoplasms: Report From A UK Center and Review of Literature
  1. Debjani Mukhopadhyay, MRCOG,
  2. Ramzi Rajab, MD, FRCPath,
  3. Marielle Nobbenhuis, MBBS, PhD,
  4. James Dilley, MRCOG,
  5. Owen Heath, MRCOG,
  6. Jayson Wang, PhD, MRCP, FRCPath,
  7. Thomas E.J. Ind, MD, MRCOG and
  8. Desmond P.J. Barton, MD, MRCOG, FRCSEd, FACOG
  1. * Department of Obstetrics and Gynaecology, Ipswich Hospital NHS Trust, Ipswich;
  2. Department of Histopathology, St George’s Hospital, London;
  3. Department of Gynaecological Oncology, The Royal Marsden Hospital, London; and
  4. § Department of Gynaecological Oncology, St George’s Hospital, London, UK.
  1. Address correspondence and reprint requests to Debjani Mukhopadhyay, MRCOG, Department of Obstetrics and Gynaecology, Ipswich Hospital NHS Trust, Heath Rd, Ipswich IP4 5PD, UK. E-mail: mukta17{at}doctors.org.uk.

Abstract

Objective This study aimed to determine the frequency of malignant pathology in a macroscopically normal appendix during surgery for a borderline or malignant mucinous ovarian tumor (MOT).

Methods Women with borderline and malignant MOT were identified from the pathology database from 2000 to 2014. Women who had a benign MOT and had an appendicectomy were excluded from the study. Data were collected from the electronic patient record and case notes.

Results Of 310 women identified with MOT, 203 patients with benign MOT were excluded. Of the remaining 107 patients, 15 patients with previous appendicectomy were also excluded. The study population consisted of 92 patients. There were 57 (62%) patients with borderline MOT and 35 (38%) patients with malignant MOT. In the borderline subgroup, 40/57 (70%) patients had appendicectomy of whom 8 (20%) had macroscopically abnormal appendices. One patient had pseudomyxoma peritonei secondarily involving the appendix and 7 patients had a histologically normal appendix. Normal histology was found in all macroscopically normal appendices. In the malignant subgroup, 29/35 (83%) patients had an appendicectomy. There were 8 (27.5%) macroscopically abnormal appendices with a malignant pathology in 7 (87.5%) patients and 1 patient had a resolving appendicitis. There were 21 macroscopically normal appendices of which, serrated adenoma was found in 1 (4.8%) patient, whereas the remaining 20 (95.2%) patients had normal histology.

Conclusions In MOT, an abnormal appearing appendix should be excised. If the appendix is grossly normal, our data do not support performing an appendicectomy as part of a surgical staging procedure.

  • Appendix
  • Ovarian tumors
  • Mucinous
  • Borderline tumors
  • Malignancy

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Footnotes

  • The authors declare no conflicts of interest.