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Cervical Cancer
Significance of the Factors Associated With Parametrial Involvement in Stage IB to IIA Cervical Cancer
  1. Xiuzhen Xie, MD,
  2. Kun Song, MD,
  3. Baoxia Cui, MD, PhD,
  4. Jie Jiang, MD, PhD,
  5. Youzhong Zhang, MD, PhD,
  6. Bo Wang, MD, PhD,
  7. Xingsheng Yang, MD, PhD and
  8. Beihua Kong, MD, PhD
  1. * Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University; and
  2. † Department of Obstetrics and Gynecology, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China.
  1. Address correspondence and reprint requests to Xingsheng Yang, MD, PhD, Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Rd, Jinan 250012, People’s Republic of China. E-mail: xingshengyang{at}sdu.edu.cn.

Abstract

Objective The aim was to explore the factors associated with parametrial involvement (PI) in patients with stage IB to IIA cervical cancer.

Materials and Methods Medical records of 507 patients were reviewed. Nine factors were analyzed by univariate analysis using χ2 test and multivariate analysis using logistic regression analysis to screen for factors associated with PI.

Results There were 46 patients with PI. Result of univariate analysis suggested depth of stromal invasion, lymphovascular space invasion (LVSI), and lymph node metastasis, and uterine involvement was associated with PI (P < 0.05 for all). The multivariate analysis model included factors that could be diagnosed by a cone biopsy, and the result suggested nonsquamous histological type and LVSI was the independent factor of PI. The incidence of PI in the patients with no LVSI and squamous cancer was 6.97%. When the patients with inner 1/3 stromal invasion were stratified into those with squamous cancer and no LVSI, the incidence of PI was 1.17%. The incidence of PI in the patients with LVSI and nonsquamous cancer was 33.33%.

Conclusions The patients with inner 1/3 stromal invasion, no LVSI, and squamous histological type may be considered for less radical surgery. The patients with nonsquamous histological type and LVSI may be considered for radical hysterectomy including a complete resection of parametrium.

  • Uterine cervical neoplasms
  • Parametrium
  • Parametrectomy
  • Radical hysterectomy

https://doi.org/10.1097/IGC.0000000000000688

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