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Pattern Recognition to Prognosticate Endometrial Cancer: The Science Behind the Art of Office Hysteroscopy—A Retrospective Study
  1. Hsuan Su, MD,
  2. Deeksha Pandey, MD,
  3. Ling-Yu Liu, PhD,
  4. Chih-Feng Yen, MD,
  5. Chin-Jung Wang, MD,
  6. Kuan-Gen Huang, MD and
  7. Chyi-Long Lee, MD, PhD
  1. * Division of Gynecologic Endoscopy, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou Chang Gung University School of Medicine, Tao-Yuan, Taiwan;
  2. Department of Obstetrics and Gynecology, KMC Manipal, Manipal University, Karnataka, India;
  3. Graduate Institute of Clinical Medical Sciences, Chang Gung University School of Medicine, Tao-Yuan, Taiwan; and
  4. § Department of Obstetrics and Gynecology, Chang GungMemorial Hospital at Keelung & Lovers Lake Branch, Keelung City, Taiwan.
  1. Address correspondence and reprint requests to Chyi-Long Lee, MD, PhD, Division of Gynecologic Endoscopy, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou 5, Fu-Hsin St, Kwei-Shan Tao-Yuan 33305, Taiwan. E-mail: leeendo{at}cgmh.org.tw.

Abstract

Objective This study aimed to evaluate a specific glomerular pattern for prognostication of endometrial cancer (EC).

Materials and Methods The office hysteroscopy’s picture and video of 4197 women were reviewed, 48 women who were suspected of type I EC were analyzed: 26 have glomerular pattern (group 1) and 22 without it (group 2).

Results The histopathological grading after hysterectomy with glomerular pattern had grade 2 or grade 3 disease on final histology (n = 25; 96%). The sensitivity and specificity of this test were 84.6% and 81.8%, respectively, with a likelihood ratio of 4:6 in predicting and prognosticating those women who have high-grade tumor or invasive disease.

Conclusions This hysteroscopic picture might be used as a novel marker for risk stratification of EC.

  • Office hysteroscopy
  • Endometrial cancer
  • Glomerular pattern
  • Risk stratification

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Footnotes

  • The authors declare no conflicts of interest.

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