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Overexpression of Siah2 Is Associated With Poor Prognosis in Patients With Epithelial Ovarian Carcinoma
  1. Ya Gao, MD,
  2. Yunduo Liu, PhD,
  3. Fanling Meng, PhD,
  4. Pan Shang, MD,
  5. Shuxiang Wang, MD,
  6. Yu Zhang, MD,
  7. Yuqi Sun, MD,
  8. Yuping Wang, MD,
  9. Jing Wang, MD and
  10. Xiuwei Chen, PhD
  1. Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
  1. Address correspondence and reprint requests Xiuwei Chen, PhD, Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, 150 Ha Ping Road, Nangang District, Harbin, Heilongjiang Province 150081, China. E-mail:


Objectives Seven in absentia homolog 2 (Siah2) is an E3 ubiquitin ligase that is expressed in mammals and is homologous to seven in absentia in Drosophila. Siah2 is involved in the progression of many malignancies. However, the role of Siah2 in ovarian cancer remains unclear. This study aims to evaluate the prognostic value of Siah2 expression for epithelial ovarian carcinoma (EOC) patients.

Materials and Methods Immunohistochemical analysis was conducted using 32 normal ovarian specimens and 122 ovarian carcinoma specimens, respectively. We analyzed the correlations of Siah2 expression with the clinicopathological factors and prognosis of ovarian cancer patients. χ2 Analysis, Kaplan-Meier method, and multivariate Cox proportional hazard analysis were conducted for statistical analyses.

Results Immunohistochemical staining demonstrated that the expression of Siah2 was higher in the EOC tissues than in the normal tissues. High Siah2 expression positively correlated with histological grade and lymph node metastasis but not with age, histologic type, International Federation of Gynecology and Obstetrics staging, and CA125. Patients with positive Siah2 expression showed lower overall survival and disease-free survival rates than those with negative Siah2 expression (P < 0.05 for both). Multivariate Cox analysis indicated that Siah2 was an independent parameter for overall survival (hazards ratio, 2.166; 95% confidence interval, 1.182–3.970; P = 0.012) and disease-free survival (hazards ratio, 1.819; 95% confidence interval, 1.030–3.216; P = 0.039).

Conclusions Siah2 is possibly involved in tumor development and progression in EOC. Thus, Siah2 is a promising biomarker for predicting the prognosis of ovarian cancer patients and may serve as a novel target for treating ovarian carcinoma.

  • Epithelial ovarian carcinoma
  • Siah2
  • Immunohistochemistry
  • Prognosis

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  • Supported by grants from the Special Research Funds for scientific and technical innovation talent of Harbin (RC2015XK004041), the National Natural Science Foundation of China (81201613), the Specialized Research Fund for the Doctoral Program of Higher Education (20122307120027), the Postdoctoral Foundation of Heilongjiang Province of China (LBH-Z11067), the scientific research project of Health Department of Heilongjiang Province (663) and the Haiyan Foundation of the Affiliated Tumor Hospital of Harbin Medical University / the Foundation of the Affiliated Tumor Hospital of Harbin Medical University (JJZ2011-04). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

  • The authors declare no conflicts of interest.