Article Text

Download PDFPDF
Location of Sentinel Lymph Node in Cervical Carcinoma and Factors Associated With Unilateral Detection
  1. Rekha Wuntakal, MD, MRCOG*,
  2. Andreas John Papadopoulos, MD, MRCOG*,
  3. Stephen Attard Montalto, MD, MRCOG*,
  4. Milica Perovic, MSc, MRCOG*,
  5. Michael Coutts, MAFRC Path, FRCPA and
  6. Omer Devaja, MD, PhD, MSc, MRCOG*
  1. *Departments of Gynaecological Oncology and
  2. Histopathology, Maidstone Hospital, Kent Oncology Centre, Maidstone, Kent, United Kingdom.
  1. Address correspondence and reprint requests to Omer Devaja, MD, PhD, MSc, MRCOG, Department of Gynaecological Oncology, Maidstone Hospital, Kent Oncology Centre, Maidstone, Kent ME16 9QQ, United Kingdom. E-mail: o.devaja{at}nhs.net.

Abstract

Objective The aims of this study were to assess locality of the sentinel lymph node (SLN) in cervical carcinoma and examine factors affecting bilateral SLN detection.

Methods This was a retrospective review of SLN data (anatomical location, count and laterality) in patients with early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA1 with lymphovascular space invasion to stage IIA) using intraoperative gamma probe and blue dye. The preoperative single-photon emission computed tomography with computed tomography was used to detect laterality, number of the SLNs, and rare locations. Patients were treated between January 2005 to January 2015 at the West Kent Gynaecological Oncology Centre, Maidstone Hospital, Maidstone, United Kingdom.

Results A total of 132 women were investigated. The most common SLN location was the external iliac (38.6%) followed by obturator (25.3%) and internal iliac (23.6%) regions. A small percentage was identified in presacral (1.4%) and para-aortic regions (0.7%). Older age (P = 0.01) and an elevated body mass index (P = 0.03) were associated with decreased SLN count by preoperative single-photon emission computed tomography with computed tomography, and only age affected SLN count by gamma probe (P = 0.01). Initial surgery, large loop excision of the transformation zone, or cone biopsy of the cervix had no effect on SLN count. There was no difference observed in bilateral detection with respect to surgical approach (open: n = 48/laparoscopic: n = 84). However, older age was independently associated with a decrease in bilateral SLN detection (P = 0.003). In these patients who underwent unilateral full pelvic lymphadenectomy, all the nonsentinel nodes were negative.

Conclusions The majority of SLNs were located in the external iliac, obturator, and internal iliac regions. Both older age and an elevated body mass index were associated with a reduced SLN count. Unilateral detection of SLN was independently associated with older age, which may be due to sclerosis in the lymphatic vessels or reduced perfusion in the pelvis in these women. If no SLN is detected on one side, the consensus is to perform a full pelvic lymphadenectomy on that side of the pelvis.

  • Cervical cancer
  • Sentinel lymph node detection
  • Sentinel lymph node location

Statistics from Altmetric.com

Footnotes

  • The authors declare no conflicts of interest.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.