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Uterine Cancer
Chemotherapy as Adjuvant Treatment for Intermediate-High Risk Early-Stage Endometrial Cancer: A Pilot Study
  1. Alessia Aloisi, MD,
  2. Francesco Plotti, MD,
  3. Giuseppe Scaletta, MD,
  4. Stella Capriglione, MD,
  5. Federica Laraud, MD,
  6. Andrea Miranda, MD,
  7. Roberto Montera, MD,
  8. Carlo De Cicco Nardone, MD,
  9. Corrado Terranova, MD and
  10. Roberto Angioli, MD
  1. Department of Obstetrics and Gynaecology, Campus Bio-Medico University of Rome, Rome, Italy.
  1. Address correspondence and reprint requests to Giuseppe Scaletta, MD, Department of Obstetrics and Gynecology, University of Rome “Campus Bio-Medico,” Via Alvaro del Portillo, 200-00128 Rome, Italy. E-mail: g.scaletta@unicampus.it.

Abstract

Objective This study aimed to assess primarily the role of chemotherapy as adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) stage IA G3, IB G2-G3, and II endometrial cancer (EC) in terms of disease-free interval and overall survival, and secondarily, the rate of local and distant recurrence.

Methods The present prospective pilot study includes 68 patients with surgical staged EC who referred between 2007 and 2011 to the Division of Gynecologic Oncology at the University Campus Bio-Medico of Rome. All enrolled patients received adjuvant chemotherapy every 3 weeks according to the scheme carboplatin, dosed at an area under the curve of 6, and paclitaxel 175 mg/mq given every 3 weeks for at least 3 cycles.

Results The median number of chemotherapy cycles was 6 (range, 3–6 cycles). Chemotherapy was well tolerated. The 3-year overall survival was 92.8% and 91.6% for stages I and II, respectively. The 3-year disease-free interval was 91.8% and 83.3% for stages I and II, respectively. Of 68 patients, 7 (10.3%) relapsed: 5 patients with a FIGO stage I and 2 patients with FIGO stage II EC.

Conclusions Platinum-based chemotherapy is feasible and safe and it could be used in adjuvant setting for early-stage ECs. Although its effectiveness is comparable to radiotherapy, chemotherapy represents an excellent treatment option due to its systemic action. Further randomized studies will be needed to confirm our promising data.

  • Endometrial cancer
  • Adjuvant chemotherapy
  • Chemotherapy
  • ntermediate-high risk
  • Early stage

https://doi.org/10.1097/IGC.0000000000000505

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    Footnotes

    • The authors declare no conflicts of interest.