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  • Role of SUVmax and GLUT-1 Expression in Determining Tumor Aggressiveness in Patients With Clinical Stage I Endometrioid Endometrial Cancer

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Uterine Cancer
Role of SUVmax and GLUT-1 Expression in Determining Tumor Aggressiveness in Patients With Clinical Stage I Endometrioid Endometrial Cancer
  1. Dong Wook Lee, MD, PhD*,
  2. Gun Oh Chong, MD*,
  3. Yoon Hee Lee, MD*,
  4. Dae Gy Hong, MD, PhD*,
  5. Young Lae Cho, MD, PhD*,
  6. Shin Young Jeong, MD, PhD†,
  7. Ji Young Park, MD, PhD‡ and
  8. Yoon Soon Lee, MD, PhD*
  1. *Departments of Obstetrics and Gynecology,
  2. †Departments of Nuclear Medicine, and
  3. ‡Departments of Pathology, School of Medicine, Kyungpook National University Medical Center, Daegu, South Korea.
  1. Address correspondence and reprint requests to Yoon Soon Lee, MD, Department of Obstetrics and Gynecology, Kyungpook National University Medical Center, 807 Hogukno, Buk-gu, 702-210 Daegu, South Korea. E-mail: yslee@knu.ac.kr.

Abstract

Objective The aim of this study was to determine the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in estimating tumor aggressiveness in patients with clinical stage I endometrial cancer and the correlation between aggressiveness and expression of glucose transporter 1 (GLUT-1).

Methods 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed on 43 patients with clinical stage I endometrioid endometrial cancer. 18F-fluorodeoxyglucose uptake was quantified by calculating the maximum standardized uptake value (SUVmax) and GLUT-1 expression status based on immunohistochemistry.

Results The mean (SD) SUVmax of the primary tumor was 8.55 (5.04). The mean SUVmax and GLUT-1 expression in stage IB and stage IC were significantly higher than that in stage IA (P = 0.001; P = 0.003). The mean (SD) SUVmax was 6.81 (4.55) in grade 1, 10.92 (4.61) in grade 2, and 15.35 (1.34) in grade 3 (grade 1 vs grade 2 and 3; P = 0.005). The mean (SD) GLUT-1 expression was 1.17 (0.94) in grade 1, 2.00 (0.94) in grade 2, and 3.00 (0.00) in grade 3 (grade 1 vs grade 2 and 3; P = 0.017).

Conclusions Tumor aggressiveness, such as myometrial invasion or tumor grade, had a positive correlation with the SUVmax and GLUT-1 expression in patients with clinical stage I endometrioid endometrial cancer.

  • Endometrial cancer
  • 18F-FDG PET/CT
  • SUVmax
  • GLUT-1
  • Tumor aggressiveness

https://doi.org/10.1097/IGC.0000000000000301

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    Footnotes

    • Dong Wook Lee and Gun Oh Chong equally contributed to this work as co-first authors.