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Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer: A Meta-Analysis
  1. Xiaolian Zhang, MMed*,
  2. Jinchun Qin, MD and
  3. Aiping Qin, MD
  1. *Departments of Clinical Laboratory,
  2. Departments of Reproductive Center, and
  3. Departments of Obstetrics and Gynecology and Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  1. Address correspondence and reprint requests to Aiping Qin, MD, Department of Obstetrics and Gynecology and Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China. E-mail:


Objective Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen that plays a vital role in angiogenesis, tumor growth, and metastasis. The associations between 3 polymorphisms of VEGF (+936C > T, −2578C > A, and −460C > T) and ovarian cancer (OC) risk have been extensively investigated, but the currently available results are inconsistent. To obtain a more accurate estimation of the association, a meta-analysis was conducted in this study.

Methods PubMed, Cochrane Library, Embase, and Chinese National Knowledge Infrastructure were searched for all relevant studies published before November 30, 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the VEGF polymorphisms to assess the strength of the association.

Results With regard to the +936C > T polymorphism, 5 articles were available for analysis (882 cases and 1155 controls), whereas for −2578C > A (559 cases and 632 controls) and −460C > T (350 cases and 409 controls), only 2 articles were eligible for analysis, respectively. A significant association between the VEGF +936C/T polymorphism and OC was demonstrated in white populations (CT vs CC: OR, 0.638 [95% CI, 0.437–0.932; P = 0.020]; TT + CT vs CC: OR, 0.694 [95% CI, 0.483-0.995; P = 0.047]). No relationship was found between −2578C > A and −460C > T and susceptibility to develop OC.

Conclusions This meta-analysis provides supportive evidence that the VEGF +936C/T polymorphism may influence the risk for the development of OC in a protective model among whites.

  • Vascular endothelial growth factor (VEGF)
  • Polymorphism
  • Ovarian cancer
  • Meta-analysis
  • Susceptibility

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  • The authors declare no conflicts of interest.