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Surgical Treatment of Microinvasive Cervical Cancer: Analysis of Pathologic Features With Implications on Radicality
  1. Juliana Yoko Yoneda, MD*,
  2. Joana Froes Braganca, PhD*,
  3. Luis Otavio Sarian, PhD*,
  4. Patrícia Patury Borba, MD,
  5. Jose Carlos J. Conceição, PhD and
  6. Luiz Carlos Zeferino, PhD*
  1. *Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil; and
  2. Brazilian National Cancer Institute (INCA), Gynecologic Oncology Division, Rio de Janeiro, RJ, Brazil.
  1. Address correspondence and reprint requests to: Joana Froes Braganca, PhD, Gynecologic Oncology Division–Department of Obstetrics and Gynecology, School of Medicine Rua Alexander Fleming, State University of Campinas (UNICAMP), 101 Cidade Universitária “Zeferino Vaz” Campinas, SP 13083-881, Brazil. E-mail: joanafbb{at}gmail.com.

Abstract

Objectives To evaluate pathologic features with implications on surgical radicality in women treated with radical hysterectomy and pelvic lymphadenectomy for cervical cancer stage IA1 with lymph vascular space invasion (LVSI) and stage IA2 by correlating findings in conization and hysterectomy specimens.

Methods Women with cervical cancer stage IA1 with LVSI and stage IA2 diagnosed by loop electrosurgical excisional procedure or cold knife conization were treated with radical hysterectomy and pelvic lymphadenectomy from January 1999 to December 2011 in 2 institutions.

Results Fifty patients were enrolled: 40 with stage IA2 and 10 with stage IA1 with LVSI. Median age was 43 (30–67) years. All patients underwent cervical conization for diagnosis (45 loop electrosurgical excisional procedure, 5 cold knife). Lymph vascular space invasion was detected in 15 patients (30%). Two patients had positive pelvic nodes. No parametrial involvement was detected in the entire cohort. Positive margins were present in 35 patients, and residual disease was detected in 22 patients (44%). Positive margins predicted residual disease at radical hysterectomy (P = 0.02). Medium follow-up time was 51 months. One patient developed a pelvic recurrence, and there were no disease-related deaths.

Conclusions Patients with positive margins in cone biopsy specimens have an increased risk of residual disease at radical hysterectomy and require careful evaluation before conservative surgery. Pelvic lymph node evaluation is essential because lymph node metastasis may occur even in early stages. The lack of parametrial invasion in this study reinforces the knowledge that the select group of patients with microinvasive cervical carcinoma stages IA1 LVSI and stage IA2 have a very low risk of parametrial infiltration. Less radical surgery can be carefully considered for these patients.

  • Uterine cervical neoplasms
  • Hysterectomy
  • Cervix uteri

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Footnotes

  • The authors declare that there are no conflicts of interest.

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