Article Text

Download PDFPDF
Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer
  1. Chengcheng Ren, MMed*,
  2. Xiaobo Li, PhD*,
  3. Tianzhen Wang, PhD*,
  4. Guangyu Wang, PhD,
  5. Ci Zhao, PhD,
  6. Tian Liang, PhD*,
  7. Yuanyuan Zhu, MMed*,
  8. Minghui Li, MMed§,
  9. Chao Yang, MMed*,
  10. Yunlong Zhao, MMed* and
  11. Guang-mei Zhang, PhD
  1. *Harbin Medical University, Harbin, China;
  2. The First Affiliated Hospital of Harbin Medical University, Harbin, China;
  3. The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China; and
  4. §Inner Mongolia Medical College, Hohhot, China.
  1. Address correspondence and reprint requests to Guang-mei Zhang, PhD, The First Affiliated Hospital of Harbin Medical University, Heilongjiang 150001, China. E-mail: guangmeizhang2014{at}163.com.

Abstract

Abstract Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.

  • LncRNA
  • Ovarian cancer
  • Gene expression
  • Gene regulation

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Footnotes

  • The authors declare no conflicts of interest.