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Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer
  1. Chengcheng Ren, MMed*,
  2. Xiaobo Li, PhD*,
  3. Tianzhen Wang, PhD*,
  4. Guangyu Wang, PhD,
  5. Ci Zhao, PhD,
  6. Tian Liang, PhD*,
  7. Yuanyuan Zhu, MMed*,
  8. Minghui Li, MMed§,
  9. Chao Yang, MMed*,
  10. Yunlong Zhao, MMed* and
  11. Guang-mei Zhang, PhD
  1. *Harbin Medical University, Harbin, China;
  2. The First Affiliated Hospital of Harbin Medical University, Harbin, China;
  3. The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China; and
  4. §Inner Mongolia Medical College, Hohhot, China.
  1. Address correspondence and reprint requests to Guang-mei Zhang, PhD, The First Affiliated Hospital of Harbin Medical University, Heilongjiang 150001, China. E-mail: guangmeizhang2014{at}


Abstract Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.

  • LncRNA
  • Ovarian cancer
  • Gene expression
  • Gene regulation

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  • The authors declare no conflicts of interest.