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Long Follow-up of Patients With Locally Advanced Cervical Cancer Treated With Concomitant Chemobrachyradiotherapy With Cisplatin and Ifosfamide Followed by Consolidation Chemotherapy
  1. Branka Petric Miše, MD*,
  2. Tihana Boraska Jelavic, MD, PhD*,
  3. Ante Strikic, MD*,
  4. Darijo Hrepic*,
  5. Krešimir Tomic, MD,
  6. Wolfgang Hamm, MD,
  7. Snježana Tomic, MD, PhD§,
  8. Tomislav Prskalo, MD* and
  9. Eduard Vrdoljak, MD, PhD*
  1. *Department of Oncology, University Hospital Split, Split, Croatia;
  2. Department of Oncology, University Hospital Mostar, Mostar, Bosnia and Herzegovina;
  3. Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; and
  4. §Department of Pathology, University Hospital Split, Split, Croatia.
  1. Address correspondence and reprint requests to Eduard Vrdoljak, MD, PhD, University Hospital Split, Spinciceva 1, HR-21000 Split, Croatia. E-mail: edo.vrdoljak{at}


Objectives Locally advanced cervical cancer (LACC) is one of the leading health problems of the developing countries. We present long-term outcomes of treatment with a concomitant chemobrachyradiotherapy followed by consolidation chemotherapy regimen.

Materials and Methods We treated 118 patients with LACC (International Federation of Gynecology and Obstetrics stages IB2-IVA) with external radiotherapy (50 Gy in 25 fractions) and concomitant chemobrachyradiotherapy (low-dose rate). Chemotherapy was applied during brachyradiotherapy (cisplatin on day 1 in combination with 24-hour infusion of ifosfamide and mesna uroprotection). Four cycles of consolidation chemotherapy were given starting 4 weeks after the second concomitant chemobrachyradiotherapy cycle.

Results After median follow-up period of 99.3 months, we observed acceptable acute and late toxicity, local control rate of 97.5%, and an overall survival of 74.6% at 96 months.

Conclusions Chemobrachyradiotherapy regimen followed by consolidation chemotherapy described in this article is a valuable treatment option for LACC.

  • Cervical cancer
  • Ifosfamide
  • Cisplatin
  • Chemobrachyradiotherapy

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  • The authors declare no conflicts of interest.