Article Text

Download PDFPDF

Gliomatosis Peritonei: A Particular Entity With Specific Outcomes Within the Growing Teratoma Syndrome
  1. Enrica Bentivegna, MD*,
  2. Clementine Gonthier, MD*,
  3. Catherine Uzan, MD, PhD*,
  4. Catherine Genestie, MD,
  5. Pierre Duvillard, MD,
  6. Philippe Morice, MD, PhD*, and
  7. Sebastien Gouy, MD, PhD*
  1. *Departments of Gynecologic Surgery, and
  2. Pathology, and
  3. UniversityParis Sud, Gustave Roussy Cancer Campus, Villejuif, France.
  1. Address correspondence and reprint requests to Philippe Morice, MD, PhD, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94805 Villejuif, France. E-mail: philippe.morice{at}


Objectives Ovarian immature teratoma may be associated with peritoneal spread that could, after adjuvant chemotherapy, develop into disease exclusively composed of mature implants (growing teratoma syndrome) and/or gliomatosis peritonei (GP), defined as the presence of pure mature glial tissue. However, very few specific series are devoted to the outcomes of pure GP. This was the aim of the present study.

Patients From 1997 to 2013, data concerning patients treated for stage II/III immature teratoma were reviewed. All slides were reviewed by an expert pathologist. Patients with ovarian cancer associated with peritoneal spread in the form of pure GP (initially if patients were treated without adjuvant treatment or after adjuvant chemotherapy if done) were analyzed.

Results Ten patients fulfilled the inclusion criteria. The median age of patients at diagnosis was 36 years (range, 14–41 years). Six patients had undergone a conservative treatment. Five patients had macroscopic residual disease at the end of surgery.

The median duration of follow-up from the diagnosis of GP was 39 months (range, 6–114 months). Six patients had undergone secondary surgery. Among them, 5 had incompletely resected macroscopic GP. No patients had died of their disease. All patients were asymptomatic at the time of the last consultation (1 of them with abnormal radiologic imaging).

Conclusions Gliomatosis peritonei is a particular entity of the condition described as growing teratoma syndrome because residual peritoneal disease can be asymptomatic totally stable over a long period which raises the question of a more conservative surgical approach in patients with massive peritoneal spread.

  • Immature ovarian teratoma
  • Growing teratoma syndrome
  • Gliomatosis peritonei
  • Recurrence
  • Follow-up

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • The authors declare no conflicts of interest.