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Trophoblastic Disease Review for Diagnosis and Management: A Joint Report From the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup
  1. Giorgia Mangili, MD*,
  2. Domenica Lorusso, MD,
  3. Jubilee Brown, MD,
  4. Jacobus Pfisterer, MD§,
  5. Leon Massuger, MD,
  6. Michelle Vaughan, MD,
  7. Hextan Y.S. Ngan, MD#,
  8. Francois Golfier, MD**,
  9. Paradan K. Sekharan, MD,,
  10. Rafael Cortés Charry, MD,,
  11. Andres Poveda, MD§§,
  12. Jae-Weon Kim, MD∥∥,
  13. Yang Xiang, MD¶¶,
  14. Ross Berkowtiz, MD## and
  15. Michael J. Seckl, PhD, FRCP***
  1. *Department of Gynecology and Obstetrics, IRCCS San Raffaele Hospital, Milan, Italy;
  2. Gynecologic Oncology Department, Catholic University of the Sacred Heart, Rome/Campobasso, Italy;
  3. Gynecologic Oncology Group, The University of Texas MD Anderson Cancer Center, Houston, TX;
  4. §AGO Study Group, Gynecologic Oncology Center, Kiel, Germany;
  5. Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands;
  6. ANZGOG, Camperdown, New South Wales, Australia;
  7. #Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital, Hong Kong, People’s Republic of China;
  8. **Centre de Référence des Maladie Trophoblastiques, Hospices Civils de Lyon, Lyon, France;
  9. ††Department of Obstetrics and Gynecology, Institute of Maternal and Child Health, Medical College, Calicut, India;
  10. ‡‡GTD unit, University Hospital of Caracas, Central University of Venezuela, Caracas, Venezuela;
  11. §§The Spanish Ovarian Cancer Research Group (GEICO), Fundación Instituto Valenciano de Oncología, Valencia, Spain;
  12. ∥∥Korean Gynaecologic Oncology Group, Seoul National University Hospital, Seoul, South Korea;
  13. ¶¶Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China;
  14. ##Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and
  15. ***Charing Cross Trophoblastic Disease Centre, Departments of Histopathology and Medical Oncology, Charing Cross Campus of Imperial College London, London, United Kingdom.
  1. Address correspondence and reprint requests to Michael J. Seckl, PhD, FRCP, Director, Charing Cross Trophoblastic Disease Centre, Department of Medical Oncology, Charing Cross Hospital Campus of Imperial College London, Fulham Palace Rd, London, W68RF, United Kingdom. E-mail: m.seckl{at}


Objective The objective of this study was to provide a consensus review on gestational trophoblastic disease diagnosis and management from the combined International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup.

Methods A joint committee representing various groups reviewed the literature obtained from PubMed searches.

Results and Conclusions Guidelines were constructed on the basis of literature review. After initial diagnosis in local centers, centralization of pathology review and ongoing care is recommended to achieve the best outcomes.

  • Gestational trophoblastic disease
  • Management
  • Diagnosis
  • Review

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  • The authors declare no conflicts of interest.