Article Text

Download PDFPDF
Maximum Standardized Uptake Value of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Is a Prognostic Factor in Ovarian Clear Cell Adenocarcinoma
  1. Haruhisa Konishi, MD*,
  2. Kazuhiro Takehara, MD, PhD*,
  3. Atsumi Kojima, MD, PhD*,
  4. Shinichi Okame, MD*,
  5. Yasuko Yamamoto, MD*,
  6. Yuko Shiroyama, MD*,
  7. Takashi Yokoyama, MD*,
  8. Takayoshi Nogawa, MD, PhD* and
  9. Yoshifumi Sugawara, MD, PhD
  1. *Departments of Gynecologic Oncology and
  2. Diagnostic Radiology, National Hospital Organization, Shikoku Cancer Center, Matsuyama, Japan.
  1. Address correspondence and reprint requests to Kazuhiro Takehara, MD, PhD, Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minami Umemoto, Matsuyama 791-0280, Japan. E-mail:


Background Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for diagnosing malignant tumors. Intracellular FDG uptake is measured as the standardized uptake value (SUV), which differs depending on tumor characteristics. This study investigated differences in maximum SUV (SUVmax) according to histologic type in ovarian epithelial cancer and the relationship of SUVmax with prognosis.

Methods This study included 80 patients with ovarian epithelial cancer based on histopathologic findings at surgery and who had undergone PET/CT before treatment. Maximum SUV on PET/CT of primary lesions and histopathology were compared based on histologic type, and the prognosis associated with different SUVmax was evaluated.

Results Clinical tumor stage was I in 35 patients, II in 8, III in 25, and IV in 12. Histologic type was serous adenocarcinoma (AC) in 33 patients, clear cell AC in 27, endometrioid AC in 15, and mucinous AC in 5. Median SUVmax was lower in mucinous AC (2.76) and clear cell AC (4.9) than in serous AC (11.4) or endometrioid AC (11.4). Overall, median SUVmax was lower in clinical stage I (5.37) than in clinical stage ≥II (10.3). However, in both clear cell AC and endometrioid AC, when histologic evaluation was possible, no difference was seen between stage I and stage ≥II. Moreover, in clear cell AC, the 5-year survival rate was significantly higher in the low-SUVmax group (100%) than in the high-SUVmax group (43.0%, P = 0.009).

Conclusions Maximum SUV on preoperative FDG-PET/CT in ovarian epithelial cancer differs according to histologic type. In clear cell AC, SUVmax may represent a prognostic factor.

  • Ovarian epithelial cancer
  • SUVmax
  • Histologic type
  • Clear cell adenocarcinoma
  • Prognosis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • The authors declare no conflicts of interest.

  • This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.