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Treatment Options for Pregnant Women With Ovarian Tumors
  1. Rosanna Mancari, MD, PhD*,
  2. Nicoletta Tomasi-Cont, MD,,
  3. Maria Anna Sarno, MD,
  4. Hatem A. Azim, MD§,
  5. Dorella Franchi, MD,
  6. Silvestro Carinelli, MD,
  7. Nicoletta Biglia, MD, PhD**,
  8. Nicoletta Colombo, MD, and
  9. Fedro Alessandro Peccatori, MD, PhD
  1. *Medical Gynecologic Oncology Division, European Institute of Oncology, Milan, Italy;
  2. Academic Division of Gynaecology and Obstetrics, Mauriziano Hospital “Umberto I,” University of Turin, Turin, Italy;
  3. Fertility and Pregnancy Unit, Medical Gynecologic Oncology Division, European Institute of Oncology, Milan, Italy;
  4. §Breast Cancer Translational Research Laboratory J.C. Heuson, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium;
  5. Preventive Gynecology Division and
  6. Pathology Division, European Institute of Oncology, Milan, Italy;
  7. **Academic Division of Gynaecology and Obstetrics, Mauriziano Hospital “Umberto I,” University of Turin, Turin, Italy; and
  8. ††Medical Gynecologic Oncology Division, European Institute of Oncology, University of Milan-Bicocca, Italy.
  1. Address correspondence and reprint requests to Mancari Rosanna, MD, PhD, European Institute of Oncology, Milan, Italy. E-mail: rosanna.mancari{at}ieo.it.

Abstract

Diagnosis of ovarian mass during pregnancy is a rare event. Treatment of ovarian malignancies during pregnancy depends on histology, grade, stage, and gestational weeks. When possible, surgical excision is indicated, and sometimes, fertility-sparing surgery is recommended. Administration of systemic treatment before or after surgery is indicated as in nonpregnant women. Preliminary data suggest that platinum salts and taxanes are safe during pregnancy. Management of ovarian tumors in pregnancy requires a multidisciplinary approach to guarantee an optimal treatment for the mother and the fetus.

  • Ovarian tumor
  • Pregnancy
  • Surgical approach
  • Systemic treatment

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Footnotes

  • Supported by Associazione Contro Tumore Ovarico onlus.

  • The authors declare no conflicts of interest.

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