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Clinicopathological Features and Survival in Young Taiwanese Women With Endometrial Carcinoma
  1. Hei-Yu Lau, MD*,,
  2. Yi-Jen Chen, MD*,,
  3. Ming-Shyen Yen, MD*,,
  4. Kuan-Chong Chao, MD*,,
  5. Ru-Fen Chen, NP,,
  6. Shu-O Yeh, NP, and
  7. Nae-Fang Twu, MD*,
  1. *Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital;
  2. Department of Obstetrics and Gynecology, National Yang-Ming University;
  3. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
  1. Address correspondence and reprint requests to Nae-Fang Twu, MD, Department of Gynecology and Obstetrics, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Rd, Taipei 112, Taiwan, Republic of China. E-mail: nftwu{at}


Objective The aim of this study is to compare the clinicopathological features and survival of young women with endometrial cancer (aged <50 years) with those of older women with endometrial cancer (aged ≥50 years).

Methods We conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the Taipei Veterans General Hospital from 2001 to 2010.

Results One hundred forty-six patients (28.5%) were aged younger than 50 years at diagnosis. The median follow-up was 36.5 months (range, 0.9–121.7 months). Low body mass index (P < 0.001), nulliparity (P < 0.001), less medical illness (P < 0.001), synchronous primary ovarian cancer (P = 0.001), endometrioid type (P = 0.005), low tumor grade (P < 0.001), no para-aortic lymph node involvement (P < 0.047), less myometrial invasion (P < 0.001), and no vascular space invasion (P = 0.001) were common among the younger women compared with the older women. There were significant differences in the disease-free survival (P = 0.006) and overall survival (P = 0.004) between the 2 groups. In the multivariate Cox model, advanced stage had an effect on both disease-free survival (P = 0.004) and overall survival (P = 0.050).

Conclusions Nulliparity, body mass index less than or equal to 23 kg/m2, endometrioid type, low-grade tumor, synchronous primary ovarian cancer, and favorable survival were common among the younger women.

  • Endometrial cancer
  • Synchronous ovarian cancer
  • Young women

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  • The authors declare no conflicts of interest.