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Radiotherapy- or Radical Surgery–Induced Female Sexual Morbidity in Stages IB and II Cervical Cancer
  1. Yuko Harding, MHSc*,
  2. Takuma Ooyama, MD*,
  3. Tomoko Nakamoto, MD*,
  4. Akihiko Wakayama, MD*,
  5. Wataru Kudaka, MD, PhD*,
  6. Morihiko Inamine, MD, PhD*,
  7. Yutaka Nagai, MD, PhD*,
  8. Shinichiro Ueda, MD, PhD and
  9. Yoichi Aoki, MD, PhD*
  1. *Department of Obstetrics and Gynecology and
  2. Clinical Pharmacology and Therapeutics, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
  1. Address correspondence and reprint requests to Yuko Harding, MHSc, Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. E-mail: yukohardinaha{at}yahoo.co.jp.

Abstract

Objective The objective of this study was to evaluate the sexual function in cervical cancer survivors after radiotherapy (RT) or radical surgery (RS).

Methods This was an observational and cross-sectional study. The Female Sexual Function Index (FSFI) self-reported questionnaires were distributed to 175 patients after RT (RT group) or RS (RS group) and 521 healthy women (control) between 2011 and 2012. Sexual functions were compared among these 3 groups.

Results Eligible 92 patients (46 in RT group, 46 in RS group) and 148 control subjects were included for analysis. There was a significant difference in median (range) FSFI total score of 5.5 (3.6–34.7) in the RT group, 18.9 (3.4–31.2) in the RS group, and 22.1 (2–34.2) in the control group (P < 0.001). The median FSFI total score in the RT group was significantly lower than that in the control group (P < 0.001). Six sexual domains (desire, arousal, lubrication, orgasm, satisfaction, pain) were all significantly affected in the RT group, and no significant differences, except pain, were observed in the RS group as compared with the control group.

Conclusions Interventions involving counseling and rehabilitation for female sexual function should be provided in cervical cancer survivors, especially after RT.

  • Cervical cancer
  • Radiotherapy
  • Radical surgery
  • Female sexual dysfunction

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Footnotes

  • The authors declare no conflicts of interest.

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