You are here

  • Home
  • Archive
  • Volume 24, Issue 4
  • Assessment of the Early Predictive Power of Quantitative Magnetic Resonance Imaging Parameters During Neoadjuvant Chemotherapy for Uterine Cervical Cancer

Article Text

Article menu
Download PDFPDF
Cervical Cancer
Assessment of the Early Predictive Power of Quantitative Magnetic Resonance Imaging Parameters During Neoadjuvant Chemotherapy for Uterine Cervical Cancer
  1. Yuki Himoto, MD*,
  2. Koji Fujimoto, MD, PhD*,
  3. Aki Kido, MD, PhD*,
  4. Noriomi Matsumura, MD, PhD†,
  5. Tsukasa Baba, MD, PhD†,
  6. Sayaka Daido, MD*,
  7. Kayo Kiguchi, MD*,
  8. Fuki Shitano, MD*,
  9. Ikuo Konishi, MD, PhD† and
  10. Kaori Togashi, MD, PhD*
  1. *Departments of Diagnostic Imaging and Nuclear Medicine, and
  2. †Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  1. Address correspondence and reprint requests to Koji Fujimoto, MD, PhD, Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. E-mail: kfb{at}kuhp.kyoto-u.ac.jp.

Abstract

Objectives The purpose of this study was to quantitatively evaluate 3 types of magnetic resonance imaging (MRI) parameters in parallel for the early prediction of neoadjuvant chemotherapy (NACT) effectiveness in cervical cancer—tumor volume parameters, diffusion parameters, and perfusion parameters.

Materials and Methods We prospectively evaluated 13 patients with International Federation of Gynecology and Obstetrics stage IB to IIB cervical squamous cell carcinoma who underwent 3 serial MRI studies, that is, pretreatment, post–first course NACT, and post–second course NACT followed by radical hysterectomy. We obtained tumor volume parameters, diffusion parameters, and dynamic contrast material–enhanced perfusion parameters quantitatively from pretreatment MRI and post–first course MRI. The correlation of these parameters and the eventual tumor volume regression rate (TVRR) obtained from pretreatment MRI and post–second course MRI before surgery were investigated, statistically based on the Pearson correlation coefficient.

Results Thirteen patients had a total of 39 scans. Early TVRR (r = 0.844; P < 0.001), the fractional volume of the tissue extracellular extravascular space (Ve, r = 0.648; P < 0.05), and the change of Ve during the first course of NACT (r = −0.638; P < 0.05) correlated with eventual TVRR.

Conclusions Early TVRR, Ve, and the change of Ve could be useful predictors for the treatment effectiveness of NACT. These parameters could help to modify strategy in the early stage of NACT and to choose individualized treatment to avoid the delay of radical treatment, even when NACT is ineffective.

  • Uterine cervical cancer
  • Neoadjuvant chemotherapy
  • Magnetic resonance imaging
  • Diffusion-weighted imaging
  • Perfusion-weighted imaging
  • Tumor volume

https://doi.org/10.1097/IGC.0000000000000124

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Footnotes

    • Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal’s Web site (www.ijgc.net).

    • The authors declare no conflicts of interest.