Article Text

Download PDFPDF
ATL
  1. Zheng-mao Zhang, MD, PhD*,
  2. Shuang Xiao, MM*,
  3. Guang-yu Sun, MM*,
  4. Yue-ping Liu, MD,
  5. Feng-hua Zhang, MD, PhD,
  6. Hong-fang Yang, MM*,
  7. Jia Li, MM*,
  8. Hong-bing Qiu, MM*,
  9. Yang Liu, MM*,
  10. Chao Zhang, PhD§,
  11. Shan Kang, MD* and
  12. Bao-en Shan, MD, PhD§
  1. *Departments of Gynecology and Obstetrics, and
  2. Pathology, Fourth Hospital of Hebei Medical University;
  3. Department of General Surgery, Hebei General Hospital; and
  4. §Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  1. Address correspondence and reprint requests to Bao-en Shan, MD, Research Center, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, China. E-mail: baoenshan{at}hbydsy.com or zzm701105{at}hotmail.com.

Abstract

Objective AT-rich interactive domain 1A (ARID1A) is a tumor suppressor gene that encodes the BAF250a protein. Recent studies have shown the loss of ARID1A expression in several types of tumors. We aimed to investigate the clinical and pathologic role of BAF250a in endometrial carcinoma.

Methods We examined the expression of BAF250a and its correlation with the expression of p53, estrogen receptor, progesterone receptor, glucocorticoid receptor, hypoxiainduciblefactor-1α, and vascular endothelial growth factor in normal and various malignant endometrial tissues.

Results The expression of BAF250 was significantly down-regulated in endometrial carcinoma when compared with normal endometrial tissues. The loss of BAF250a expression was found in 25% of endometrial carcinoma samples but not in normal endometrial tissues, complex endometrial hyperplasia, and atypical endometrial hyperplasia samples. Subtypes of endometrial carcinoma, especially uterine endometrioid carcinoma and uterine clear cell carcinoma, had higher frequency of loss of BAF250a expression. In addition, the expression of BAF250a was positively correlated with estrogen receptor and negatively correlated with p53 in poorly differentiated endometrial adenocarcinoma. Moreover, the expression of BAF250a was significantly associated with the differentiation status of endometrial carcinoma but not associated with clinical stage, the depth of myometrial invasion, lymph node metastasis, and overall survival of patients with endometrial carcinoma.

Conclusions Our data showed that loss of BAF250a is frequently found in high-grade endometrioid and clear cell carcinomas but not in other types of endometrial carcinoma. The loss of BAF250a expression does not have prognostic value for endometrial carcinoma.

  • Endometrial carcinoma
  • ARID1A
  • BAF250a
  • p53
  • Estrogen receptor

Statistics from Altmetric.com

Footnotes

  • This study is supported by the Hebei Personnel Institute Postgraduate Scholarship Grants and the Nature Science Foundation of Hebei Province.

  • The authors declare no conflicts of interest.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.