Article Text

Download PDFPDF
Association Between Reproductive Cancer and Fetal Outcomes: A Systematic Review
  1. Mulubrhan F. Mogos, PhD*,
  2. Shams Rahman, MD*,
  3. Hamisu M. Salihu, MD, PhD*,,
  4. Abraham A. Salinas-Miranda, MD, MPH* and
  5. Dawood H. Sultan, PhD
  1. *Maternal and Child Health Comparative Effectiveness Research Group, Department of Epidemiology and Biostatistics, College of Public Health;
  2. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine;
  3. Department of Health Policy and Management, College of Public Health, University of South Florida, Tampa, FL.
  1. Address correspondence and reprint requests to Hamisu M. Salihu, MD, PhD, University of South Florida, College of Public Health, Department of Epidemiology and Biostatistics, 13201 Bruce B. Downs Blvd, MDC 56, Tampa, FL 33612. E-mail: hsalihu{at}


Objective This study aimed to review studies that addressed the impact of previous reproductive cancer diagnosis on selected fetal birth outcomes.

Materials and Methods We searched PubMed and Web of Knowledge to identify peer-reviewed articles published from January 1992 to December 2012, investigating the association between reproductive cancer and birth outcomes. After applying exclusion criteria, 49 articles were identified for full review, and 36 articles were finally selected for this systematic review. The quality of the studies was assessed by independent reviewers.

Results We found 13 cervical cancer studies, 16 ovarian cancer studies, and 7 corpus uteri cancers that reported subsequent pregnancies (n = 688 pregnancies in 477 women). Of these, 489 pregnancies reached third trimester. Among viable pregnancies, only 416 pregnancies had information on maturity status based on gestational age and/or birth weight. For those with cervical cancer, the preterm birth (PTB) rate was 48.5%. For those with ovarian cancer, there were no cases of PTB. For those with corpus uteri cancers, the PTB was 7.7%. All studies had small sample sizes, and there was considerable heterogeneity of results. Abortions, ectopic pregnancies, and terminations were also reported.

Conclusions Reproductive cancers may be associated to subsequent adverse fetal birth outcomes; however, the quality of evidence is still insufficient to infer a relationship between reproductive cancers treated conservatively and adverse fetal birth outcomes in subsequent pregnancies.

  • Fetal outcomes
  • Low birth weight
  • Pregnancy
  • Preterm
  • Reproductive cancer
  • Small size for gestational age

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • The authors declare no conflicts of interest.

  • This work was supported by a funding from the Agency for Health Care Research and Quality (AHRQ) through a grant on Clinically Enhanced Multi-Purpose Administrative Dataset for Comparative Effectiveness Research” (Award#: 1R0111HS019997; and National Institutes of Health through a grant on Cancer health disparities (award no. 1P20MD003375-01) and the Agency for Health Care Research and Quality through a grant on Clinically Enhanced Multi-Purpose Administrative Data set for Comparative Effectiveness Research (award no. 1R0111HS019997).