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Aberrant Expression of E-Cadherin and Integrin β-1 in Trophoblasts Is Associated With Malignant Gestational Trophoblastic Diseases
  1. Huimin Shu, MS*,
  2. Hua Chen, MS*,
  3. Binlie Yang, MS,
  4. Zhuolin Chang, MS*,
  5. Miao Xiong, MS and
  6. Weixiang Chen, MD*
  1. *Department of Obstetrics and Gynecology, Gongli Hospital, Pudong New Area, Shanghai, China,
  2. Department of Obstetrics and Gynecology, The People’s Hospital of the Pudong New Area, Shanghai, China; and
  3. Sixth People’s Hospital affiliated to Shanghai Jiaotong University, Shanghai, China.
  1. Address correspondence and reprint requests to Binlie Yang, MS, Department of Obstetric and Gynecology, the People’s Hospital of the Pudong New Area, Shanghai 201200, China. E-mail:


Objective To investigate the association between malignant gestational trophoblastic diseases and aberrant local expression of E-cadherin and integrin β-1 in the context of identifying a method to predict and diagnose malignant gestational trophoblastic diseases at an early stage.

Methods We used immunohistochemistry to assess E-cadherin and integrin β-1 expression profiles in normal chorionic villus, hydatidiform mole, and invasive mole.

Results E-cadherin expression gradually decreased from normal tissue to malignant tissue. Staining for E-cadherin was positive in 90% of normal trophoblastic villus in early pregnancy, 80% in benign hydatidiform mole, and 50% in invasive mole. Notably, invasive mole had significantly lower E-cadherin expression than benign mole (P < 0.05). However, there was no significant difference in staining between benign and malignant moles (15% vs 10%, P > 0.05). Integrin β-1 expression was identical in benign hydatidiform mole and malignant mole (90% and 90%), but this value was significantly higher than that in normal trophoblastic villus (40%, both P < 0.05). Moreover, malignant mole staining was significantly higher than in the benign mole (30% vs 15%, P < 0.05).

Conclusions Aberrant expression of E-cadherin and integrin β-1 is closely related to malignant transformation and hydatidiform mole development. Changes in the expression of E-cadherin and integrin β-1 are informative and may improve the early diagnosis of malignant/invasive moles.

  • Hydatidiform mole
  • Invasive mole
  • Choriocarcinoma
  • E-cadherin
  • Integrin β-1

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  • Huimin Shu, MS, and Hua Chen, MS, contributed equally to this work.

  • The authors declare no conflicts of interest.