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Clinical Significance of Yes-Associated Protein Overexpression in Cervical Carcinoma: The Differential Effects Based on Histotypes
  1. Tianbo Liu, PhD*,
  2. Yunduo Liu, PhD*,
  3. Hongyu Gao, MD,
  4. Fanling Meng, PhD*,
  5. Shanshan Yang, PhD* and
  6. Ge Lou, PhD*
  1. *Departments of Gynecology and
  2. Departments of Gastroenterologic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
  1. Address correspondence and reprint requests to Ge Lou, PhD, Department of Gynecology, The Third Affiliated Hospital, Harbin Medical University, 150 Haping Rd, Harbin 150081, China. E-mail:


Objectives The objective of this study was to explore the prognostic values of Yes-associated protein (YAP) expression in cervical carcinoma.

Methods We compared the YAP expression of 120 samples from squamous cell carcinomas (SCCs) and 42 samples from adenocarcinomas with 22 normal cervical specimens by immunohistochemistry. The expressions of cytoplasmic and nuclear YAP were analyzed separately.

Result Yes-associated protein expression in tumors is significantly higher than the level in normal tissues. In SCCs, cytoplasmic YAP expression is associated with histologic grading, lymph node metastasis, and recurrence. Nuclear expression of YAP is absent in SCC. In adenocarcinomas, cytoplasmic YAP overexpression is associated with histologic grading, and nuclear overexpression is associated with shorter overall survival and disease-free survival.

Conclusions Our results indicate the oncogenic potential of YAP in cervical cancer and its distinct functions in SCC and adenocarcinoma.

  • Yes-associated protein
  • Immunohistochemistry
  • Cervix
  • Squamous cell carcinoma
  • Adenocarcinoma

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  • The authors declare no conflicts of interest.