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Clinicopathologic Features of Gestational Trophoblastic Neoplasia in the Limpopo Province, South Africa
  1. Louis-Jacques Jean van Bogaert, MD, PhD, DPhil
  1. National Health Laboratory Service and the Polokwane Campus of the University of Limpopo, Polokwane, Limpopo, South Africa.
  1. Address correspondence and reprint requests to Louis-Jacques Jean van Bogaert, Post Net Suite 7, Private Bag x8689, Groblersdal 0470, South Africa. E-mail: louis.vanBogaert{at}


Abstract The pathogenesis of gestational trophoblastic neoplasia (GTN) is complex; various etiological factors influence the wide variety of its distribution throughout the world. Gestational trophoblastic neoplasia encompasses a spectrum of benign and malignant lesions. The relative prevalence of benign versus malignant cases varies geographically. Most GTNs are benign and located in the uterus; benign and malignant GTNs do also arise outside the uterine body. Tubal hydatid moles (HMs) and primary choriocarcinomas are rare. Over a 3-year period, 119 cases of biopsy-diagnosed GTNs were prospectively collected: 70.6% were benign and 29.4% were malignant. Two HMs, or 2.4% of all HMs, were located in the tubes; 2 choriocarcinomas, or 6.5% of all malignant GTNs, originated in the tubes. Tubal GTNs accounted for 0.5% of 857 tubal ectopic pregnancies. There was no significant difference in the mean age of benign and malignant GTNs (P = 0.61). Four (11.4%) of the 35 malignant GTNs were HIV infected.

  • Gestational trophoblastic disease
  • Hydatid mole
  • Choriocarcinoma
  • Fallopian tube

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  • The author did not receive funding for this work.

  • The author declares no conflict of interest.