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P27 as a Prognostic Factor of Early Cervical Carcinoma
  1. Jiri Bouda, MD, PhD*,
  2. Ondrej Hes, MD, PhD,
  3. Miroslava Koprivova, MD,
  4. Martin Pesek, MD*,
  5. Tomas Svoboda, MD and
  6. Ludmila Boudova, MD, PhD
  1. *Departments of Obstetrics and Gynecology,
  2. Pathology, and
  3. Radiotherapy, Medical Faculty Hospital, Charles University, Plzen, Czech Republic.
  1. Address correspondence and reprint requests to Jiri Bouda, MD, PhD, Department of Obstetrics and Gynecology, Medical Faculty Hospital, Alej Svobody 80, 304 06 Plzen, Czech Republic. E-mail: boudaj{at}


Objective The aim of this study was to clarify whether the evaluation of cell-cycle regulatory protein p27 can serve as a prognostic factor in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical carcinoma.

Patients and Methods A retrospective study was performed on 130 surgically treated patients with FIGO stage IB cervical carcinoma with at least a 5-year follow-up. The expression of p27 was investigated independently by 2 experienced pathologists using immunohistochemistry. The prognostic significance of established prognostic factors and p27 expression were analyzed using univariate and multivariate analyses.

Results In a univariate analysis, lymph node status, tumor diameter, Gynecologic Oncology Group (GOG) score, lymph vascular space invasion, and p27 expression were significant prognostic factors for overall survival (OS). We found a correlation between p27 expression and lymph node status, tumor diameter, invasion, and GOG score. The p27 expression was a statistically significant prognostic factor for OS in a univariate analysis (log-rank test, P = 0.03). In a multivariate analysis, only lymph node status and tumor diameter were statistically significant prognostic factors for OS.

Conclusions This study demonstrated that a low p27 expression is associated with lymph node metastasis, deep stromal invasion, tumor diameter more than 20 mm, and high GOG score and had a prognostic influence on OS in a univariate analysis in a series of 130 women with FIGO stage IB cervical carcinoma. Lymph node status and the diameter of the tumor were the only statistically significant prognostic factors in multivariate analysis.

  • P27
  • Cervical carcinoma
  • Prognostic factors

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  • The authors declare no conflicts of interest.