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  • G801A Polymorphism of Human Stromal Cell–Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix

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Basic Science
G801A Polymorphism of Human Stromal Cell–Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix
  1. Yi-Torng Tee, MD, PhD*,†,‡,
  2. Shun-Fa Yang, PhD*,§∥,
  3. Po-Hui Wang, MD, PhD*,†,‡,
  4. Hsiu-Ting Tsai, PhD,#,**,
  5. Long-Yau Lin, MD, PhD*,†,‡,
  6. Shu-Kuei Lee, MD,#,**,
  7. Chiung-Ling Liao, MD, PhD*,†,‡,
  8. Jinghau Tsai Chang, PhD* and
  9. Yang-Tse Shih, MD†,‡
  1. *Institute of Medicine, Chung Shan Medical University;
  2. †Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital;
  3. ‡School of Medicine, Chung Shan Medical University; Departments of
  4. §Medical Research and
  5. ∥Clinical Laboratory, Chung Shan Medical University Hospital;
  6. College of Nursing, Chung Shan Medical University;
  7. #Department of Nursing, Chung Shan Medical University Hospital; and
  8. **Institute of Nursing, Chung Shan Medical University, Taichung, Taiwan.
  1. Address correspondence and reprint requests to Yang-Tse Shih, MD, Jinghau Tsai Chang, PhD, and Chiung-Ling Liao, MD, PhD, Institute of Medicine and School of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Rd, Taichung, 40201, Taiwan. E-mail: bc00070935{at}yahoo.com.tw.

Abstract

Objective This study aimed to investigate the association of stromal cell–derived factor 1 (SDF-1) gene polymorphisms with the neoplastic lesions of uterine cervix in Mid-Taiwan women.

Materials and Methods Four hundred ninety-eight blood samples were collected from 161 patients with neoplasia of uterine cervix, including 76 cancer patients, 61 patients with high-grade dysplasia, and 24 with low-grade dysplasia, and 337 healthy controls who lived in Mid-Taiwan. Polymorphism of the SDF-1 gene was examined using polymerase chain reaction–restriction fragment length polymorphism.

Results For SDF-1 gene polymorphisms, the wild-type homozygous alleles (G/G) yielded 100- and 193-bp products, the heterozygous alleles (G/A) yielded 100-, 193- and 293-bp products, whereas the mutated-type homozygous alleles (A/A) yielded a 293-bp product. We found no significant difference in genotypes or alleles distribution of SDF-1 polymorphisms between patients with cervical neoplasia and healthy women (P = 0.530). Compared with the homozygous GG subgroup, GA and AA subgroups do not increase the risk of cervical neoplasia.

Conclusions Although the expression of SDF-1 was reported to be significantly increased in cervical carcinogenesis in previous studies, our results, however, show that SDF-1 gene polymorphism could not be considered as a factor related to an increased susceptibility to cervical neoplasia.

  • Stromal cell–derived factor 1 gene
  • Single nucleotide polymorphisms
  • Neoplasia of uterine cervix

https://doi.org/10.1097/IGC.0b013e318265d334

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    Footnotes

    • Supported by the Taiwan National Science Council (NSC 97-2314-B-040- 028) and the Chung Shan Medical University Hospital, Taiwan (CSH-2011-C-005).

    • The authors declare no conflicts of interest.