Article Text

Download PDFPDF
G801A Polymorphism of Human Stromal Cell–Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix
  1. Yi-Torng Tee, MD, PhD*,,,
  2. Shun-Fa Yang, PhD*,§,
  3. Po-Hui Wang, MD, PhD*,,,
  4. Hsiu-Ting Tsai, PhD,#,**,
  5. Long-Yau Lin, MD, PhD*,,,
  6. Shu-Kuei Lee, MD,#,**,
  7. Chiung-Ling Liao, MD, PhD*,,,
  8. Jinghau Tsai Chang, PhD* and
  9. Yang-Tse Shih, MD,
  1. *Institute of Medicine, Chung Shan Medical University;
  2. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital;
  3. School of Medicine, Chung Shan Medical University; Departments of
  4. §Medical Research and
  5. Clinical Laboratory, Chung Shan Medical University Hospital;
  6. College of Nursing, Chung Shan Medical University;
  7. #Department of Nursing, Chung Shan Medical University Hospital; and
  8. **Institute of Nursing, Chung Shan Medical University, Taichung, Taiwan.
  1. Address correspondence and reprint requests to Yang-Tse Shih, MD, Jinghau Tsai Chang, PhD, and Chiung-Ling Liao, MD, PhD, Institute of Medicine and School of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Rd, Taichung, 40201, Taiwan. E-mail: bc00070935{at}yahoo.com.tw.

Abstract

Objective This study aimed to investigate the association of stromal cell–derived factor 1 (SDF-1) gene polymorphisms with the neoplastic lesions of uterine cervix in Mid-Taiwan women.

Materials and Methods Four hundred ninety-eight blood samples were collected from 161 patients with neoplasia of uterine cervix, including 76 cancer patients, 61 patients with high-grade dysplasia, and 24 with low-grade dysplasia, and 337 healthy controls who lived in Mid-Taiwan. Polymorphism of the SDF-1 gene was examined using polymerase chain reaction–restriction fragment length polymorphism.

Results For SDF-1 gene polymorphisms, the wild-type homozygous alleles (G/G) yielded 100- and 193-bp products, the heterozygous alleles (G/A) yielded 100-, 193- and 293-bp products, whereas the mutated-type homozygous alleles (A/A) yielded a 293-bp product. We found no significant difference in genotypes or alleles distribution of SDF-1 polymorphisms between patients with cervical neoplasia and healthy women (P = 0.530). Compared with the homozygous GG subgroup, GA and AA subgroups do not increase the risk of cervical neoplasia.

Conclusions Although the expression of SDF-1 was reported to be significantly increased in cervical carcinogenesis in previous studies, our results, however, show that SDF-1 gene polymorphism could not be considered as a factor related to an increased susceptibility to cervical neoplasia.

  • Stromal cell–derived factor 1 gene
  • Single nucleotide polymorphisms
  • Neoplasia of uterine cervix

Statistics from Altmetric.com

Footnotes

  • Supported by the Taiwan National Science Council (NSC 97-2314-B-040- 028) and the Chung Shan Medical University Hospital, Taiwan (CSH-2011-C-005).

  • The authors declare no conflicts of interest.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.