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Prospective Assessment of Quality of Life and Psychological Distress in Patients With Gynecologic Malignancy: A 1-Year Prospective Study
  1. Guler Yavas, MD*,
  2. Nasuh Utku Dogan, MD,
  3. Cagdas Yavas, MD,
  4. Nilgun Benzer, MD,
  5. Deniz Yuce, MD§ and
  6. Cetin Celik, MD
  1. *Departments of Radiation Oncology and
  2. Departments of Obstetrics and Gynecology, Selcuklu Faculty of Medicine, Selcuk University;
  3. Departments of Department of Radiation Oncology, Konya Training and Research Hospital, Konya; and
  4. §Departments of Department of Preventive Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  1. Address correspondence and reprint requests to Nasuh Utku Dogan, MD, Department of Obstetrics and Gynecology, Selcuklu School of Medicine, Selcuk University, 42 075 Selijuks, Konya, Turkey. E-mail: nasuhutkudogan{at}


Objective Our aim was to evaluate the health-related quality of life (HRQoL) and psychological distress in patients treated with radiotherapy (RT) for gynecologic malignancy.

Methods Fifty-seven women with either cervical or endometrial cancer were prospectively enrolled. We assessed HRQoL at baseline (after surgery before RT), at the end of RT, and during follow-up (every 3 months thereafter) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30), European Organization for Research and Treatment of Cervical Cancer Quality of Life Questionnaire 24 (EORTC QLQ-CX24), and Hospital Anxiety and Depression Scale.

Results We demonstrated changes in appetite loss (P = 0.03), nausea and vomiting (P = 0.02), and role function score (P = 0.003) domains of EORTC QLQ-C30. Only the mean body image score of EORTC QLQ-CX24 was significantly different during follow-up (P = 0.02). Type of surgery, histopathological diagnosis, and the menopausal and marital status of the patients affected baseline body image scores (P = 0.032, 0.004, and 0.019 and 0.005, respectively). Patients who underwent chemotherapy had higher baseline body image scores when compared with patients without any chemotherapy before RT (P = 0.028). All the complaints of patients except body image scores improved during the follow-up period. The baseline and follow-up anxiety and depression scores did not differ significantly.

Conclusions Although pelvic RT deteriorated HRQoL in gynecologic cancer, patients’ improvement in HRQoL during follow-up was observed. Patients receiving RT could be reassured about the improvement of acute adverse effects in the course of treatment.

  • Health-related quality of life
  • Gynecological malignancy
  • Psychological distress
  • Radiotherapy

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  • The authors declare that there are no conflicts of interest.