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Tumor-Infiltrating Dendritic Cells May Be Used as Clinicopathologic Prognostic Factors in Endometrial Carcinoma
  1. Zhao Lijun, PhD, MD*,
  2. Zhao Xin, MD*,,
  3. Shen Danhua, MD,
  4. Li Xiaoping, PhD, MD*,
  5. Wang Jianliu, MD*,
  6. Wang Huilan, MD and
  7. Wei Lihui, MD*
  1. *Department of Obstetrics and Gynecology, Peking University People’s Hospital, Beijing;
  2. Department of Obstetrics and Gynecology, The second Hospital of HeBei Medical University, Shijiazhuang; and
  3. Department of Pathology, Peking University People’s Hospital, Beijing, China.
  1. Address correspondence and reprint requests to Wei Lihui, MD, Department of Obstetrics and Gynecology, Peking University People’s Hospital, Beijing, 100044, China. E-mail: weilh19@china.com

Abstract

Objective To investigate the distribution of dendritic cells (DCs) at different development status in endometrial carcinoma and their relationship with clinical pathology.

Methods Samples were collected from 95 patients with endometrial endometrioid adenocarcinoma treated in Peking University People’s Hospital from 2002 to 2010. Normal endometrial tissue was obtained from 40 women and served as controls. Immunohistochemistry was used to detect the expression of S100-, human leukocyte antigen (HLA)-DR–, and CD1a-positive DCs within the tumor glandular epithelium, the surrounding tumor interstitial tissue, and the equivalent normal endometrial tissue. The relationship of these DCs with clinical stage, pathology grade, myometrial invasion, and lymph node metastasis was analyzed.

Results The rate of S100-positive DCs in the endometrial endometrioid adenocarcinoma glandular epithelium samples from the 95 patients was 48.4% (46/95), and that of the HLA-DR–positive DCs was 27.4% (26/95), which were both significantly higher (P < 0.05) than that in the control group. CD1a-positive DC was rarely expressed in endometrial endometrioid adenocarcinoma glandular epithelium. The rates of the S100- and HLA-DR–positive DCs in tumor interstitial tissue were similar to that of the control group (both, P > 0.05). The proportion of invasion of the S100- and HLA-DR–positive DCs was negatively correlated with the clinical stage and lymph node metastasis but was not correlated with the pathological grade and myometrial invasion.

Conclusions Dendritic cell invasion was detected in endometrial endometrioid adenocarcinoma. S100- and HLA-DR–positive DCs may have functions related to the delay of tumor progression and lymph node metastasis.

  • Dendritic cell
  • S100
  • HLA-DR
  • CD1a
  • Endometrial endometrioid adenocarcinoma

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Footnotes

  • Zhao Lijun and Zhao Xin contributed equally to this work.

  • This work was supported by the funds of Peking University Health Science Centre 985 construction project, stage III (BMU20100064).

  • The authors have no financial disclosures.

  • Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal’s Web site (www.ijgc.net).

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