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Sexual Function After Intracavitary Vaginal Brachytherapy for Early-Stage Endometrial Carcinoma
  1. Allison M. Quick, MD*,
  2. Leigh G. Seamon, DO, MPH,
  3. Mahmoud Abdel-Rasoul, MPH,
  4. Ritu Salani, MD, MBA§ and
  5. Douglas Martin, MD
  1. *Department of Radiation Oncology, The Ohio State University Medical Center, Stephanie Spielman Comprehensive Breast Center, Columbus, OH;
  2. Division of Gynecologic Oncology, Spectrum Health Medical Group and Department of Obstetrics, Gynecology and Women’s Health, Michigan State University Grand Rapids, MI;
  3. Department of Biostatistics, and
  4. §Division of Gynecologic Oncology, and
  5. Department of Radiation Oncology, The Ohio State University Medical Center, Columbus, OH.
  1. Address correspondence and reprint requests to Allison Quick, MD, Department of Radiation Oncology, Stephanie Spielman Comprehensive Breast Center, Columbus, OH, 43212. E-mail:


Objective To describe the effects of intracavitary brachytherapy (IVB) on sexual function and quality of life of women with early-stage endometrial cancer.

Methods Women with International Federation of Gynecology and Obstetrics stage I to stage II endometrial cancer treated surgically with or without IVB were identified and mailed questionnaires. Quality of life and sexual function were measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the cervical cancer disease-specific module. Pertinent data from prior surgery and radiation treatments were abstracted retrospectively. Linear transformation of the survey subscale scores was conducted per European Organization for Research and Treatment of Cancer guidelines.

Results Sixteen women in the IVB arm and 53 in the surgery-alone group completed the survey. Of the sexually active patients, 33% of the IVB patients and 42% of the surgery-alone patients felt their vagina was dry during sexual activity (P = 0.804) and 17% versus 20% felt their vagina was short (P = 0.884). Seventeen percent of patients in the IVB group felt their vagina was tight compared to 29% in the surgery-alone group (P = 0.891) and 0% versus 14% of patients reported pain during intercourse (P = 0.808). There was no statistically significant difference in sexual/vaginal functioning, sexual worry, or sexual enjoyment between the 2 groups.

Conclusions Although both groups report vaginal changes that may affect sexual function, the patients treated with IVB reported similar outcomes on a sexual function questionnaire compared to patients treated with surgery alone.

  • Sexual function
  • Endometrial cancer
  • Intracavitary brachytherapy
  • Quality of life

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  • The research was funded by the Department of Radiation Oncology at The Ohio State University Medical Center and in part by Award Number UL1RR025755 from the National Center for Research Resources for statistical analysis.

  • Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal’s Web site (