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Increased Expression of Dachshund Homolog 1 in Ovarian Cancer as a Predictor for Poor Outcome
  1. Fei Liang, MD*,
  2. Qingtao Lü, PhD,
  3. Shuyu Sun, MD,
  4. Jie Zhou, PhD§,
  5. Vladimir M. Popov, PhD,
  6. Shaoru Li, MD*,
  7. Weihua Li, MD*,
  8. Yang Liu, MD*,
  9. Jie Jiang, MD, PhD* and
  10. Beihua Kong, PhD, MD*
  1. * Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University;
  2. Shandong University of Traditional Chinese Medicine;
  3. The university-affiliated Hospital, Shandong University, Jinan, Shandong;
  4. § Department of Endocrinology and Metabolism, Xijing Hospital, the Fourth Military Medical University, Xi’an, Shanxi, China; and
  5. Department of Cancer Biology, Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA.
  1. Address correspondence and reprint requests to Jie Jiang, MD, PhD, Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, China. E-mail: qljiangjie{at}sdu.edu.cn.

Abstract

Objective This study aimed to determine the functional relationship between the levels of dachshund homolog 1 (DACH1) expression and different subtypes of ovarian cancer and to investigate the possible prognostic value of DACH1 in ovarian cancer.

Methods Immunohistochemical staining was deployed to determine the protein levels of DACH1. Staining was performed on patient samples, for whom the detailed follow-up data have been acquired during the last 10 years. Normal, benign, borderline, cancer, and metastatic ovarian cancer samples were included in this study.

Results The results of our study show that DACH1 protein levels increase with the invasiveness of the ovarian cancer. As the cancer progresses from benign and borderline to metastatic, DACH1 protein expression increases as well. Moreover, with the increase in expression, the subcellular distribution of DACH1 changes from nucleus in normal tissue to cytoplasm in cancer. Finally, DACH1 expression levels were compared with estrogen receptor α (ERα) levels, and the results showed that overall DACH1 levels were higher, whereas also DACH1 exhibited increased cytoplasmic expression in ERα-positive ovarian cancer samples.

Conclusions These results indicate that DACH1 is highly expressed in metastatic ovarian cancer compared with that of normal, benign, and borderline ovarian tissues and that it could play an important role in cancer growth.

  • Dachshund homolog 1
  • Ovarian cancer
  • Estrogen receptor
  • Metastasis

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Footnotes

  • The authors declare that there are no conflicts of interest.

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