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A Single Nucleotide Polymorphism in EXO1 Gene Is Associated With Cervical Cancer Susceptibility in Chinese Patients
  1. Xiping Luo, MD*,
  2. Xiao-Shan Hong, MD*,,
  3. Xing-Dong Xiong, MD,
  4. Li-Qin Zeng, MD and
  5. Chi Eung Danforn Lim, MBBS, MMed, MAppSc(Acup), MAppMgt(Health), PhD, DCH§
  1. *Guangdong Women and Children’s Hospital, Guangzhou;
  2. Guangzhou Medical University, Guangzhou, Guangdong;
  3. Aging Institute, Guangdong Medical University, Dongguan, Guangdong, P.R. China; and
  4. §South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
  1. Address correspondence and reprint requests to Chi Eung Danforn Lim, MBBS, MMed, MAppSc(Acup), MAppMgt(Health), PhD, DCH, PO Box 3256, Blakehurst, NSW 2221, Australia. E-mail: celim@unswalumni.com.

Abstract

Objective The aim of this study was to investigate the association of Exonuclease1 (EXO1) genetic polymorphism and the development of cervical carcinoma.

Methods This study was conducted with 126 patients diagnosed with cervical cancer and 278 people with no cancer history. The polymerase chain reaction–based restriction fragment length polymorphism was used to evaluate the K589E and C908G gene polymorphisms. Unconditional logistic regression analysis was used to estimate the association between the genotypes and the risk for cervical cancer.

Results This is the first study on the role of EXO1 K589E (rs1047840) and EXO1 C908G (rs10802996) polymorphisms in cervical cancer in a Chinese population. Our results indicated that the EXO1 K589G polymorphism were significantly associated with the risk for cervical cancer. Compared with the G allele EXO1 K589E, the A allele increased the risk for cervical cancer (adjusted odds ratio, 1.67; 95% confidence interval, 1.13–2.45). By contrast, we have not found a significant association between the EXO1 C908G polymorphism and cervical cancer risk (P = 0.791).

Conclusion These findings indicate that the SNPs of EXO1 K589E may contribute to cervical cancer carcinogenesis in Chinese populations. A larger population study will need to be carried out to further validate the potential association of EXO1 genetic polymorphism and cervical carcinoma.

  • EXO1
  • Cervical cancer
  • Single nucleotide polymorphism

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Footnotes

  • Luo and Hong contributed equally to this work.

  • Funding received for this research study was from Project of Medical Research Fund of Guangdong Province Government, China (No. 2010068).

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