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Tumor Necrosis Factor α −308 G>A Polymorphisms and Cervical Cancer Risk: A Meta-Analysis
  1. Bo Ding, PhD*,
  2. Shilong Fu, MD*,
  3. Meilin Wang, MD,
  4. Cong Yue, PhD*,
  5. Wei Wang, PhD,
  6. Delan Zhou, MD*,
  7. Zhengdong Zhang, MD and
  8. Suping Han, MD*
  1. *Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing; and
  2. Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
  1. Address correspondence and reprint requests to Suping Han, MD, Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China. E-mail: hansuping@gmail.com.

Abstract

Objective Tumor necrosis factor α (TNF-α), secreted mainly by activated macrophages, is recently involved in fighting against tumorigenesis. Tumor necrosis factor α −308 G>A, the common polymorphism in the promoter of TNF-α, has been implicated to alter the risk of cervical cancer, yet the results of relative studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed a meta-analysis based on 8 studies.

Methods A comprehensive search was conducted to examine all the eligible studies of TNF-α −308 G>A polymorphism and cervical cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.

Results Eight studies regarding TNF-α −308 G>A polymorphism status including 2298 cases and 1903 controls were collected. Overall, significantly elevated cervical cancer risk was found for A allele versus G allele (OR, 1.25; 95% CI, 1.10–1.42), for GA versus GG (OR, 1.33; 95% CI, 1.14–1.54), and for GA/AA versus GG (OR, 1.31; 95% CI, 1.14–1.52). In the subgroup analysis by ethnicity, significantly increased risks were also found among whites (for A allele vs G allele: OR, 1.16; 95% CI, 1.00–1.34; for GA vs GG: OR, 1.24; 95% CI, 1.05–1.48; and for GA/AA vs GG: OR, 1.22; 95% CI, 1.03–1.44) and Asians (for A allele vs G allele: OR, 2.36; 95% CI, 1.60–3.50; AA vs GG: OR, 3.85; 95% CI, 1.30–11.37; for GA vs GG: OR, 2.06; 95% CI, 1.30–3.27; GA/AA vs GG: OR, 2.29; 95% CI, 1.49–3.52; and for AA vs GA/GG: OR, 3.70; 95% CI, 1.25–10.81). However, no significant associations were found among Africans for all genetic models.

Conclusions The natural genetic polymorphism in TNF-α −308 G>A is a risk factor for developing cervical cancer, especially for Asians and whites.

  • TNF-α
  • Cervical cancer
  • Polymorphism
  • Meta-analysis

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Footnotes

  • Ding and Fu Contributed equally.

  • The authors declare that there is no conflict of interest.

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