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Basic Science
Association of Survivin Gene Polymorphism With Endometrial Cancer
  1. Parisa Zahedi, MSc*,
  2. Soheila Aminimoghaddam, MD†,
  3. Forough A. Sayahpour, BSc*,
  4. Vahid Haghpanah, MD*,
  5. Parvin Amiri, MSc*,
  6. Forozandeh Fereidoni, MD‡,
  7. Elnaz Mahrampour, BSc*,
  8. Bagher Larijani, MD*,
  9. Javad Tavakkoly-Bazzaz, MD, PhD* and
  10. Mahsa M. Amoli, MD, PhD*
  1. * Endocrinology and Metabolism Research Centre,
  2. † Gynecology Department, Firoozgar Hospital, and
  3. ‡ Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
  1. Address correspondence and reprint requests to Mahsa M. Amoli, MD, PhD, Endocrinology and Metabolism Research Centre (EMRC), Dr Shariati Hospital, North Karegar Street, Tehran 14114, Iran. E-mail: amolimm{at}tums.ac.ir.

Abstract

Objective Survivin is an inhibitor of apoptosis protein, which is up-regulated in endometrial cancer (EC). A promoter region polymorphism (−31G/C) in the survivin gene has been reported as a modulator of gene expression. The aim of this study was to explore the frequency of survivin −31G/C polymorphism in tumor tissues from patients with EC in an Iranian population compared to that of healthy controls.

Materials and Methods Paraffin-embedded tissue sections from patients diagnosed with EC (n = 31) and healthy controls (n = 30) were examined. Genotyping for survivin −31G/C polymorphism was performed using polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP).

Results The presence of allele C was found to be significantly increased in EC tissues compared to the healthy tissues (GG vs GC + CC, P = 0. 01; OR, 3.6; 95% CI, 1.1–11.9).

Conclusion Our data are in keeping with a previous finding regarding the role of survivin gene polymorphism in malignancies. This finding highlights the role of survivin in pathogenesis of various carcinomas, which might have therapeutic implications.

  • Survivin
  • Gene
  • Polymorphism
  • Endometrial cancer

https://doi.org/10.1097/IGC.0b013e318229902c

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