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Radical Vaginal Trachelectomy (RVT) Combined With Laparoscopic Lymphadenectomy: Prospective Study of 225 Patients With Early-Stage Cervical Cancer
  1. Malgorzata Lanowska, MD*,
  2. Mandy Mangler, MD*,
  3. Annabel Spek, Cand Med*,
  4. Ulrike Grittner, PhD,
  5. Kati Hasenbein, MD*,
  6. Vito Chiantera, MD*,
  7. Hermann Hertel, MD,
  8. Achim Schneider, MD, MPH*,
  9. Christhardt Köhler, MD* and
  10. Dorothee Speiser, MD*
  1. *Department of Gynecology, Charité University Medicine, Berlin, Germany;
  2. Department of Biometrics and Clinical Epidemiology, Charité University Medicine, Berlin, Germany; and
  3. Department of Gynecology, Medical School Hannover, Hannover, Germany.
  1. Address correspondence and reprint requests to Malgorzata Lanowska, MD, Department of Gynecology, Charite˙ Universitätsmedizin Berlin, Campus Mitte and Benjamin Franklin, Charitéplatz 1, D-10117 Berlin, Germany. E-mail: malgorzata.lanowska{at}


Objective: The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood.

Methods: A database of 225 patients with early-stage cervical cancer and intention to treat by RVT after laparoscopic lymphadenectomy was prospectively maintained. A total of 212 patients were treated according to the protocol. The procedure was preformed in a standardized manner, and life table analysis was applied.

Results: In the cohort of patients treated according to protocol, 8 recurrences occurred and 4 patients died from recurrence. The median follow-up time was 37 months (range, 0-171 months). The 5-year recurrence-free and overall survival was 94.4% and 97.4%, respectively. Perioperative and short-term postoperative complications were rare (2.8% and 7.5%, respectively). No severe long-term complications occurred.

Conclusions: Radical vaginal trachelectomy combined with laparoscopic lymphadenectomy is a safe method for treatment of patients with early-stage cervical cancer who are seeking parenthood.

  • Early-stage cervical cancer
  • Radical vaginal trachelectomy
  • Fertility-preserving surgery
  • Laparoscopic lymphadenectomy

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  • There were no sources of support for this work.

  • The authors declare that there are no conflicts of interest.