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A Single-Institution Evaluation of Factors Important in Fallopian Tube Carcinoma Recurrence and Survival
  1. Alireza A. Shamshirsaz, MD*,
  2. Thomas Buekers, MD,
  3. Koen DeGeest, MD,
  4. David Bender, MD,
  5. Gideon Zamba, PhD and
  6. Michael J. Goodheart, MD
  1. *Department of Obstetrics and Gynecology,
  2. Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics Holden Comprehensive Cancer Center; and
  3. Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA.
  1. Address correspondence and reprint requests to Michael J. Goodheart, MD, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 4630 JCP, 200 Hawkins Dr, Iowa City, IA 52242. E-mail: michael-goodheart{at}


Objective: The aim of this study was to identify prognostic factors and markers that influence clinical outcomes in patients with primary fallopian tube carcinoma at a single tertiary health care center. These prognostic factors may be of clinical importance and can subsequently be included in future clinical trials.

Materials and Methods: A retrospective review of our Tumor Registry and Gynecologic Oncology database was conducted to include any patients with a diagnosis of fallopian tube carcinoma between the years 1994 and 2005. We identified clinicopathological data to evaluate factors important in recurrence, disease-specific and overall survival. Kaplan-Meier curves were generated, and log-rank tests were used to evaluate survival differences.

Results: Thirty-six patients had a diagnosis with primary fallopian tube carcinoma at a median age of 69 years. Patients most frequently presented with abdominal pain (19%) and a palpable mass (14%). The most common histological subtype was papillary serous adenocarcinoma in 56% of cases. Stage III disease (39%) and poorly differentiated tumors (81%) were most common. The median follow-up was 39.6 months. The 5-year cancer-specific survival was 42%, and the overall survival rate was 34%. Factors important in disease-free survival were International Federation of Gynecology and Obstetrics stage, tumor laterality, and serum CA-125, whereas International Federation of Gynecology and Obstetrics stage, serum CA-125, and residual disease were prognostic factors for overall survival. The most common locations of recurrence were pelvis and abdomen (63%) as opposed to distant sites. Factors associated with recurrence were stage, tumor laterality, and serum CA-125.

Conclusions: Fallopian tube malignancies are rare. We have identified factors associated with recurrence, disease specific survival, and overall survival that could be further examined and included in larger clinical trials involving this uncommon malignancy.

  • Fallopian tube carcinoma
  • Prognostic factors
  • Survival
  • Laterality

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  • No funding was received for this work.