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Thromboembolic Event as a Prognostic Factor for the Survival of Patients With Stage IIIB Cervical Cancer
  1. Marcos José Pereira Renni, MD*,
  2. Fábio Bastos Russomano, PhD,
  3. Luiz Figueiredo Mathias, MD* and
  4. Hilton Augusto Koch, PhD
  1. * Instituto Nacional de Câncer, Ministério da Saúde,
  2. Instituto Fernades Figueira/Fiocruz, Ministério da Saúde and
  3. Universidade Federal do Rio de Janeiro, HUCFF, Rio de Janeiro, Brazil.
  1. Address correspondence and reprint requests to Marcos José Pereira Renni, MD, Largo dos Leões 63/201, Rio de Janeiro, 22260210, Brazil. E-mail: mjrenni{at}; mrenni{at}


Objective: The purpose of this study was to evaluate the effect of thromboembolic event (TEE) on the prognosis and survival of women diagnosed with the International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer undergoing treatment at the National Cancer Institute (Instituto Nacional de Câncer [INCA], Ministério da Saúde), Brazil.

Methods: A total of 1020 women with FIGO stage IIIB cervical cancer (International Classification of Diseases, C53.9), who had received treatment at this institute between 2000 and 2004, were identified. Data were obtained from the hospital cancer registry at INCA. Patients were followed up from the date of their diagnosis of cervical cancer at INCA until their death or last follow-up visit. The date of TEE diagnosis was defined as the date of one of the following tests diagnosing this condition: Doppler ultrasound scan, computed tomography scan, or in 1 single case echocardiography. The Kaplan-Meyer method was used to perform long-term survival analysis.

Conclusions: The presence of TEE in patients with FIGO stage IIIB cervical cancer seems to be indicative of the severity of the disease and poorer prognosis. The most important finding is that in the patients who developed TEE, this complication occurred around the time of diagnosis of progression of the disease. Disease progression may have been the triggering factor for the development of TEE.

  • Thrombosis
  • Prognosis
  • Survival
  • Cervical cancer

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