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Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia
  1. Christoph Grimm, MD*,
  2. Rafal Watrowski, MD*,
  3. Stephan Polterauer, MD,
  4. Konstantin Baumühlner, MD*,
  5. Camilla Natter, MD*,
  6. Jasmin Rahhal, MD*,
  7. Georg Heinze, PhD,
  8. Eva Schuster, PhD*,
  9. Lukas Hefler, MD§ and
  10. Alexander Reinthaller, MD*
  1. * Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;
  2. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY;
  3. Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Vienna; and
  4. § Karl Landsteiner Institute for Gynecologic Surgery and Oncology, Vienna, Austria.
  1. Address correspondence and reprint requests to Christoph Grimm, MD, Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. E-mail: christoph.grimm{at}meduniwien.ac.at.

Abstract

Objective: To evaluate the association between 3 vascular endothelial growth factor (VEGF) gene polymorphisms and susceptibility of cervical intraepithelial neoplasia (CIN).

Materials and Methods: This prospectively collected case-control study investigates three common VEGF gene polymorphisms (ie, VEGF −460 [rs833061], VEGF +405 [rs2010963], and VEGF +936 [rs3025039]) in 203 women with CIN and 209 healthy women by DNA pyrosequencing. Associations between polymorphisms and CIN risk are evaluated with univariate and multivariable models and haplotype analysis.

Results: In a multivariable regression model, the variant VEGF +405C allele was associated (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.2-5.1], P = 0.02) with increased susceptibility of CIN independent of number of sexual partners (OR, 2.2; 95% CI, 1.1-4.6; P = 0.03) and smoking (OR, 3.3; 95% CI, 1.6-6.6; P = 0.001). The haplotype VEGF −460C - +405C - +936C was associated with an OR of 5.2 (95% CI, 1.2-52.7) for the susceptibility of CIN.

Conclusions: The presence of the variant VEGF +405C allele and the haplotype VEGF −460C - +405C - +936C are independently associated with higher susceptibility of CIN.

  • Vascular endothelial growth factor
  • Gene
  • Polymorphism
  • Cervical intraepithelial neoplasia

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Footnotes

  • The authors declare that they have no competing interests.

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