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Impact of Human Papillomavirus-Related Lesions on Quality of Life: A Multicenter Hospital-Based Study of Women in Mainland China
  1. Shao-Ming Wang, MD*,
  2. Ju-Fang Shi, MD, PhD*,,
  3. Dian-Ju Kang, MD*,,
  4. Philip Song, BA§ and
  5. You-Lin Qiao, MD, PhD*
  1. * Department of Cancer Epidemiology, Cancer Institute of Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;
  2. Cancer Epidemiology Research Unit, Cancer Council New South Wales, New South Wales, Australia;
  3. Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China; and
  4. § Johns Hopkins School of Medicine, Baltimore, MD.
  1. Address correspondence and reprint requests to You-Lin Qiao, MD, PhD, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, 17 S Panjiayuan Ln, Chaoyang District, Beijing, 100021 China. E-mail: qiaoy{at}


Introduction: To date, few studies using a human papillomavirus (HPV)-specific questionnaire have focused on the impact of quality of life (QoL) among women with HPV-related lesions in developing countries.

Methods: A multicenter, hospital-based survey was conducted from 2007 to 2008. Women 18 to 65 years old who had HPV-related lesions or underwent HPV-related screening interventions during the past 3 months were recruited and divided into 6 groups based on different diagnoses: (1) normal Papanicolaou (Pap) test result, (2) abnormal Pap test result without HPV test, (3) external genital warts (GWs), (4) precancerous cervical lesions (confirmed by histological diagnoses), (5) HPV positive (HPV+) after abnormal Pap test result, and (6) HPV negative (HPV−) after abnormal Pap test result. Psychosocial burdens were assessed by the HPV impact profile (HIP). The HIP contains 7 domains and 29 questions, and its scores reversely relates to the subjects' QoL.

Results: A total of 2605 eligible women were enrolled. Women with GWs had the highest mean HIP scores (52.2), followed by the group with precancerous cervical lesions (48.6), HPV+ after abnormal Pap (45.8), abnormal Pap test result without HPV test (44.1), HPV− after abnormal Pap (43.1), and women with normal Pap endured the least (33.1). "Sexual impact," "self-image," and "control/life impact" were the 3 QoL-related domains that affected women the most. The psychosocial burden of urban residents was heavier than that of rural women.

Conclusions: Women with GWs and precancerous cervical lesions had the worst psychological burden, and sexual-related concern was the primary cause of burdens regarding HPV-related diseases for Chinese women. In addition to basic medical treatments, psychosocial support systems should be established, and consultation services should be generalized to help alleviate these burdens.

  • Quality of life (QoL)
  • Psychosocial burden
  • HPV-related lesions
  • Chinese women

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