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Gestational Trophoblastic Neoplasm
No Association Between Serum Paraoxonase, Arylesterase Activities, and Hydatidiform Mole
  1. Ebru Ozturk, MD*,
  2. Ozcan Balat, MD*,
  3. Ebru Dikensoy, MD*,
  4. Mete Gurol Ugur, MD*,
  5. Caglayan Ozcan, MD*,
  6. Abdullah Aydin, MD†,
  7. Ozcan Erel, MD‡ and
  8. Seval Kul, Assistant Professor§
  1. * Departments of Obstetrics and Gynecology and
  2. † Pathology, Gaziantep University, Gaziantep;
  3. ‡ Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara; and
  4. § Department of Biostatistics, Gaziantep University, Gaziantep, Turkey.
  1. Address correspondence and reprint requests to Ebru Ozturk, MD, Gaziantep Universitesi Tıp Fakültesi, Kadın Hastalıkları ve Dogum AD, Kilis Yolu Uzeri, Sahinbey Uygulama ve Arastırma Hastanesi, 27310, Sahinbey, Gaziantep, Turkey. E-mail: ebruozturkarslan{at}yahoo.com.

Abstract

Background: In this study, we aimed to evaluate the association between hydatidiform mole (HM) and paraoxonase 1 (PON1) activity and phenotyping in comparison with healthy subjects (both pregnant and nonpregnant women).

Methods: Eighty women were enrolled in this study. Of these, 26 had HM (group 1). Twenty-seven healthy women in the first trimester of pregnancy with a single viable fetus were included in the study as control subjects (group 2). The remaining 27 subjects were healthy nonpregnant women who also participated as control subjects (group 3). Paraoxonase and arylesterase activities were measured using commercially available kits (Relassay, Gaziantep, Turkey). Paraoxonase activity measurements were performed both in the absence (basal activity) and presence of NaCl (salt-stimulated activity). The phenotype distribution of PON1 activity was determined by the double-substrate method.

Results: Basal and salt-stimulated paraoxonase and arylesterase activities were not significantly different between the HM, healthy pregnant control, and healthy nonpregnant control groups. Hence, PON1 phenotype distribution of the subjects was not significantly different between these 3 groups.

Conclusions: We determined no association between HM (complete or partial) and PON1 activity and phenotyping in comparison with pregnant and nonpregnant healthy subjects. Further studies including metastatic or invasive HM are needed.

  • Paraoxonase
  • Arylesterase
  • Hydatidiform mole

https://doi.org/10.1097/IGC.0b013e3182021c59

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