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Neoadjuvant Chemotherapy Followed by Radical Vaginal Trachelectomy and Adjuvant Chemotherapy for Clear Cell Cancer of the Cervix: A Feasible Approach and Review
  1. Piksi Singh, MS, FRANZCOG, CGO*,
  2. James Nicklin, FRANZCOG, CGO* and
  3. Timothy Hassall, MBBS (Qld), FRACP (PAeds)
  1. * Queensland Centre for Gynaecological Cancer, Royal Brisbane and Women's Hospital; and
  2. Royal Children's Hospital, Brisbane, Australia.
  1. Address correspondence and reprint requests to Piksi Singh, MS, FRANZCOG, CGO, Queensland Centre for Gynaecological Cancer, Level 6, Ned Hanlon Bldg, Royal Brisbane and Women's Hospital, Herston 4029, Australia. E-mail: drpiksi5{at}


Background: Clear cell adenocarcinoma of the cervix (CCAC) may affect pediatric and younger women in absence of diethylstilbestrol exposure and other classic predisposing factors for cervical cancer. Prognosis is similar for early-stage CCAC, squamous cell cancer and non-clear cell adenocarcinoma of the cervix. Vaginal radical trachelectomy (VRT) and abdominal radical trachelectomy (ART) with pelvic lymph node dissection have evolved as valuable fertility-preserving treatment options. Neoadjuvant chemotherapy (NACT) before abdominal radical trachelectomy/VRT may reduce tumor size and thereby facilitate surgery. In some cases, adjuvant treatment in the presence of high-risk prognostic features may be required to optimize treatment.

Methods: A 13-year-old adolescent with International Federation of Obstetrics and Gynecology stage IB1 CCAC was treated with NACT using carboplatin and paclitaxel (CP) followed by laparoscopic pelvic lymphadenectomy, VRT, and adjuvant chemotherapy.

Results: Neoadjuvant chemotherapy using CP was well tolerated with no toxicity. Neoadjuvant chemotherapy reduced the tumor size and facilitated radical vaginal trachelectomy. Adjuvant treatment was recommended in the presence of risk factors. The patient elected to conserve the uterus and underwent 3 further cycles of adjuvant chemotherapy with CP.

Conclusions: This is the first reported case of CCAC treated with NACT using CP followed by laparoscopic pelvic lymphadenectomy, VRT, and adjuvant chemotherapy. A successful treatment outcome achieved using this novel approach suggests its applicability in selected cases.

  • Clear cell adenocarcinoma of the cervix
  • Squamous cell carcinoma
  • Vaginal radical trachelectomy
  • Abdominal radical trachelectomy
  • Neoadjuvant chemotherapy

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