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The Effects of Parity, Breastfeeding, and Infertility Treatment on the Risk of Hereditary Breast and Ovarian Cancer: A Review
  1. Ami Fishman, MD
  1. Department of Obstetrics and Gynecology, Meir Medical Center, Kfar-Saba, Israel.
  1. Address correspondence and reprint requests to Ami Fishman, MD, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, 44281 Israel. E-mail: amifishman{at}


Knowledge of the potential association of parity, breastfeeding, and infertility treatment on breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers is important and should be a crucial part of genetic counseling. The discussion of parity and clinical management of infertility in these women is complex, and patient preferences should be considered. Ideally, these preferences should be informed by accurate information on the risks and benefits of the interventions considered. However, this important subject has been investigated in a relatively small number of studies, thus, the existing data remain somewhat limited, and the estimated risk of cancer in BRCA mutation carriers is imprecise.

  • Parity
  • Breastfeeding
  • Infertility treatment
  • Hereditary breast and ovarian cancer

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