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Ovarian Cancer
Prognostic and Predictive Values of E-Cadherin for Patients of Ovarian Clear Cell Adenocarcinoma
  1. Chih-Ming Ho, MD, PhD*,†,‡,
  2. Wen-Fang Cheng, MD, PhD§,
  3. Ming-Chieh Lin, MD∥,
  4. Tze-Chien Chen, MD,
  5. Shih-Hung Huang, MD#,
  6. Fu-Shing Liu, MD**,
  7. Chan-Chao Chang Chien, MD†,‡,
  8. Mu-Hsien Yu, MD, PhD†,‡,
  9. Tao-Yeuan Wang, MD§§ and
  10. Chang-Yao Hsieh, MD, MSPH§
  1. * Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital;
  2. † School of Medicine, Fu Jen Catholic University, Hsinchuang, Taipei Hsien;
  3. ‡ School of Medicine, Taipei Medical University; Departments of
  4. § Obstetrics and Gynecology and
  5. ∥ Pathology, National Taiwan University Hospital;
  6. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and
  7. # Department of Pathology, Cathay General Hospital;
  8. ** Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung;
  9. †† Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung;
  10. ‡‡ Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Tri-Service General Hospital; and
  11. §§ Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan.
  1. Address correspondence and reprint requests to Chang-Yao Hsieh, MD, MSPH, Department of Obstetrics and Gynecology, National Taiwan University Hospital, 7 Chung-Shan S Rd, Taipei 100, Taiwan. E-mail: changyaohsieh{at}yahoo.com.tw.

Abstract

Objectives: The purpose of the study was to analyze negative versus positive immunoexpression of epithelial cadherin (E-cadherin) and p53 in patients with primary advanced ovarian clear cell adenocarcinoma (OCCA) and its significance in relation to clinical features, progression-free survival and overall survival (OS).

Methods and Materials: Protein expression of E-cadherin and p53 was immunohistochemically evaluated in 61 OCCA patients with stages IIC to IV. The clinical factors studied included stage, age, CA-125, residual tumors, and chemotherapy regimens.

Results: Positive p53 immunoexpression was 44.8% (26/58) of OCCAs; in contrast, E-cadherin immunoexpression was observed in 75.9% (44/58) of OCCAs. The expected 5-year OS rate of OCCA treated with paclitaxel-based chemotherapy was significantly better than non-paclitaxel-based chemotherapy (40% vs 0%, P = 0.001). The expected 5-year OS rate of OCCA patients with positive E-cadherin immunoexpression (>10%) was also significantly better than patients with negative E-cadherin immunoexpression (≤10%) (35% vs 0%, P = 0.02). The expected 5-year OS rate of those receiving paclitaxel-platinum chemotherapy was not significantly different from platinum-based chemotherapy for those with negative E-cadherin immunoexpression (P = 0.11). The expected 5-year OS rate of those receiving paclitaxel-based chemotherapy was better than non-paclitaxel-based chemotherapy for those with positive E-cadherin immunoexpression (43% vs 0%, P = 0.01). Paclitaxel-based chemotherapy and positive E-cadherin immunoexpression were 2 independent prognostic factors in OS of patients with OCCA (P = 0.01 and 0.04, respectively).

Conclusions: E-cadherin is a useful prognostic marker for OCCA patients, and paclitaxel-based chemotherapy can improve survival among patients with positive E-cadherin immunoreactivity.

  • Ovarian carcinoma
  • Clear cell carcinoma
  • Paclitaxel
  • Chemotherapy
  • E-cadherin

http://dx.doi.org/10.1111/IGC.0b013e3181e68a4d

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