Article Text

Download PDFPDF
Cost-Effectiveness Analysis of Prophylactic Cervical Cancer Vaccination in Japanese Women
  1. Ryo Konno, MD, PhD*,
  2. Toshiyuki Sasagawa, MD, PhD,
  3. Takashi Fukuda, PhD,
  4. Georges Van Kriekinge§ and
  5. Nadia Demarteau§
  1. *Department of Obstetrics and Gynecology, Saitama Medical Centre, Jichi Medical University, Saitama;
  2. Reproductive and Perinatal Medicine (Obstetrics & Gynecology), Kanazawa Medical University, Kanazawa;
  3. Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and
  4. §Health Economics, GlaxoSmithKline Biologicals, Rixensart, Belgium.
  1. Address correspondence and reprint requests to Ryo Konno, MD, PhD, Department of Obstetrics and Gynecology, SaitamaMedical Centre, Jichi Medical University 1-847 Amanuma-cho, Omiya, Saitama, 330-8503 Japan. E-mail: kryo772007{at}


Introduction: The incidence of cervical cancer (CC) is high in Japan and is further increasing among women younger than 30 years. This burden could be reduced by the implementation of a CC vaccine, but its cost-effectiveness is unknown.

Methods: We quantified the clinical impact and assessed the cost-effectiveness of adding CC vaccination at age 12 to the current screening in place in Japan with a lifetime Markov model adapted to the Japanese setting. Transition probabilities and utility values were obtained from public databases. Direct costs for treatment and screening were estimated using Japanese medical fees. Annual costs and benefits were discounted at 3%. Sensitivity analyses were conducted on the age at vaccination, the vaccine characteristics, the discount rates, the proportion of human papillomavirus types 16/18 in cancer, and the screening coverage.

Results: Vaccinating a 12-year-old cohort was predicted to reduce CC incidence and deaths from CC by 73%. These clinical effects were associated with an incremental cost-effectiveness ratio of ¥1.8 million per quality-adjusted life year gained. The incremental cost-effectiveness ratio of vaccinating all 10- to 45-year-old women was ¥2.8 million per quality-adjusted life year, still below the threshold value.

Conclusions: The implementation of a CC vaccination in Japan could reduce the CC burden in a very cost-effective manner for women up to 45 years.

  • Cost-effectiveness
  • HPV vaccination
  • Japan

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • This study was supported by a grant from GlaxoSmithKline K.K Japan. R. Konno received research and travel grants and honoraria for courses and conferences from GlaxoSmithKline Japan, Merck Japan, and Qiagen Japan. He is a member of the Advisory/Expert Board at GlaxoSmithKline Biologicals. This study was also supported by GlaxoSmithKline Biologicals, where authors Van Kriekinge and Demarteau are currently employed.